Disease Models, Animal

Publication Title: 
Journal of Toxicology and Environmental Health. Part A

The use of dietary adsorbents to reduce arsenic (As) exposure is innovative. Ferrihydrite successfully sorbs arsenite and asenate over a wide range of pH conditions and the As-ferrihydrite complexes are stable in gastrointestinal (GIT) models.

Author(s): 
Taylor, John F.
Robinson, Abraham
Mitchell, Nicole J.
Marroquin-Cardona, Alicia
Johnson, Natalie
Elmore, Sarah E.
Romoser, Amelia A.
Phillips, Timothy D.
Publication Title: 
Aging Cell

In laboratory animals, calorie restriction (CR) protects against aging, oxidative stress, and neurodegenerative pathologies. Reduced levels of growth hormone and IGF-1, which mediate some of the protective effects of CR, can also extend longevity and/or protect against age-related diseases in rodents and humans. However, severely restricted diets are difficult to maintain and are associated with chronically low weight and other major side effects.

Author(s): 
Parrella, Edoardo
Maxim, Tom
Maialetti, Francesca
Zhang, Lu
Wan, Junxiang
Wei, Min
Cohen, Pinchas
Fontana, Luigi
Longo, Valter D.
Publication Title: 
Experimental Gerontology

Dietary or calorie restriction (DR, CR), defined as reduced food intake without malnutrition, imparts many benefits in model organisms. Extended longevity is the most popularized benefit but the least clinically relevant due to the requirement for long-term food restriction. DR also promotes stress resistance and metabolic fitness. Emerging data in experimental models and in humans indicate that these benefits occur rapidly upon initiation of DR, suggesting potential clinical relevance.

Author(s): 
Robertson, Lauren T.
Mitchell, James R.
Publication Title: 
Obesity (Silver Spring, Md.)

OBJECTIVE: Increasing prevalence of childhood obesity and associated risks of adult type disease have led to worldwide concern. It remains unclear how genetic predisposition, environmental exposure to obesogenic food, and developmental programming interact to lead to overweight and obese children. The development of a nonhuman primate model of obesity, and particularly juvenile obesity, is an important step to elucidating the factors associated with obesity and evaluating intervention strategies. DESIGN AND METHODS: Infant marmosets were followed from birth to 12 months of age.

Author(s): 
Ross, Corinna N.
Power, Michael L.
Artavia, Joselyn M.
Tardif, Suzette D.
Publication Title: 
Current Opinion in Clinical Nutrition and Metabolic Care

PURPOSE OF REVIEW: Recent findings suggest that high-sugar diets can lead to cognitive impairment predisposing to neurodegenerative disorders such as Alzheimer's disease. This article discusses metabolic derangements induced by high-fructose/sucrose diets and presents evidence for the involvement of insulin resistance in sporadic Alzheimer's disease pathogenesis. RECENT FINDINGS: There has been much concern regarding the role of dietary sugars (fructose/sucrose) in the development of type 2 diabetes (T2D).

Author(s): 
Moreira, Paula I.
Publication Title: 
Journal of Neuro-Oncology

Regardless of their cell type of origin, all aggressive brain tumors, such as malignant gliomas and metastatic tumors produce brain edema, which is an important cause of patient morbidity and mortality. Caloric restriction (CR) has long been recognized as a natural therapy that improves health, promotes longevity, and significantly reduces both the incidence and growth of many tumor types. The aim of present work was to investigate the effect of CR on edema and survival in the mice implanted with U87 gliomas.

Author(s): 
Jiang, Yong-Sheng
Wang, Fu-Rong
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Mutations causing decreased somatotrophic signaling are known to increase insulin sensitivity and extend life span in mammals. Caloric restriction and every other day (EOD) dietary regimens are associated with similar improvements to insulin signaling and longevity in normal mice; however, these interventions fail to increase insulin sensitivity or life span in growth hormone receptor knockout (GHRKO) mice.

Author(s): 
Westbrook, Reyhan
Bonkowski, Michael S.
Arum, Oge
Strader, April D.
Bartke, Andrzej
Publication Title: 
Aging Cell

Cockayne syndrome (CS) is a rare autosomal recessive segmental progeria characterized by growth failure, lipodystrophy, neurological abnormalities, and photosensitivity, but without skin cancer predisposition. Cockayne syndrome life expectancy ranges from 5 to 16 years for the two most severe forms (types II and I, respectively). Mouse models of CS have thus far been of limited value due to either very mild phenotypes, or premature death during postnatal development prior to weaning. The cause of death in severe CS models is unknown, but has been attributed to extremely rapid aging.

Author(s): 
Brace, Lear E.
Vose, Sarah C.
Vargas, Dorathy F.
Zhao, Shuangyun
Wang, Xiu-Ping
Mitchell, James R.
Publication Title: 
Current Opinion in Pharmacology

Neurochemical and structural prefrontal cortex abnormalities, including decreased reelin and glutamic acid decarboxylase (GAD)(67) expression, decreased thickness, increased neuronal packing density and decreased neuropil and dendritic spine number, are characteristics of schizophrenia neuropathology. Reelin is an extracellular matrix protein secreted by GABAergic interneurons that, acting through pyramidal neuron integrin receptors, provides a signal for dendritic spine plasticity.

Author(s): 
Costa, Erminio
Davis, John
Pesold, Christine
Tueting, Patricia
Guidotti, Alessandro
Publication Title: 
Trends in Neurosciences

Our understanding of human disorders that affect higher cognitive functions has greatly advanced in recent decades, and over 20 genes associated with non-syndromic mental retardation have been identified during the past 15 years. However, proteins encoded by "cognition genes" have such diverse neurodevelopmental functions that delineating specific pathogenetic pathways still poses a tremendous challenge.

Author(s): 
Persico, Antonio M.
Bourgeron, Thomas

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