Publication Title: 
Journal of Evaluation in Clinical Practice

Null hypothesis significance testing is the typical statistical approach in search of the truthfulness of hypotheses. This method does not formally consider the prior credence in the hypothesis, which affects the chances of reaching correct conclusions. When scientifically implausible or empirically weakly supported hypotheses are tested, there is an increased risk that a positive finding in a test in fact is false positive.

Lytsy, Per
Publication Title: 
Acupuncture in Medicine: Journal of the British Medical Acupuncture Society

BACKGROUND: Acupuncture analgesia has been evaluated by a number of randomised controlled trials (RCTs); however, a systematic summary of reporting quality of RCTs in this specific field is lacking. OBJECTIVE: To examine the reporting characteristics and risk of bias of RCTs of acupuncture analgesia indexed in the PubMed database. METHODS: A PubMed search of RCTs of acupuncture analgesia was conducted through November 2015. The Cochrane Collaboration Risk of Bias Tool was used to assess the risk of bias of each trial.

Li, Xiuxia
Wang, Rong
Shi, Xiue
Chen, Zehao
Pan, Yuanqing
Li, Xusheng
Yang, Kehu
Publication Title: 
BMJ open

OBJECTIVES: This study aims to assess the completeness of reporting of randomised controlled trials (RCTs) of acupuncture in the Korean literature. DESIGN: Systematic review. METHODS: We searched 12 Korean databases and 7 Korean journals to identify eligible RCTs of acupuncture published from 1996 to July 2011. We used the Consolidated Standards of Reporting Trials (CONSORT) checklist for parallel RCTs and the revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) to assess the quality of reporting in Korean RCTs.

Kim, Kun Hyung
Kang, Jung Won
Lee, Myeong Soo
Lee, Jae-Dong
Publication Title: 
Acupuncture in Medicine: Journal of the British Medical Acupuncture Society

OBJECTIVE: By reviewing the assessment of internal validity in relevant systematic reviews (SRs), the aim of this study was to identify how critical appraisals of risk of bias (RoB) inform the synthesis of evidence in SRs of acupuncture for pain relief. METHODS: SRs were searched in Medline, EMBASE, and the Cochrane Database of SRs from their inception to 30 December 2014. Only SRs of acupuncture for pain relief were included.

Li, Xiao-qian
Tao, Kun-ming
Yang, Ge-liang
Zhou, Qing-hui
Ling, Chang-quan
Publication Title: 
Progress in Clinical and Biological Research
Butler, R. N.
Publication Title: 
Nutrition Reviews
Matsuzaki, T.
Publication Title: 
La Revue Du Praticien
Belmin, JoÎl
Konrat, CÈcile
Publication Title: 
Journal of Epidemiology and Community Health

During the past two decades, research concerned with the aetiology of psychopathology has generally progressed along two separate paths: investigations that have characterised the roles played by environmental determinants such as childhood adversity in the development of psychopathology, and those that have focused on neurobiological processes involving genetic and intracellular pathways.

El-Sayed, Abdulrahman M.
Koenen, Karestan C.
Galea, Sandro
Publication Title: 
Journal of Neurology, Neurosurgery, and Psychiatry

BACKGROUND: Adult onset primary torsion dystonia (AOPTD) is a poorly penetrant autosomal dominant disorder; most gene carriers are non-manifesting despite having reached an adequate age for penetrance. It is hypothesised that genetic, epigenetic and environmental factors may exert protective or deleterious effects on penetrance of AOPTD. By examining environmental exposure history in cervical dystonia patients and their similarly aged unaffected siblings we aimed to determine the role of previous environmental exposures in relation to disease penetrance.

Molloy, Anna
Kimmich, Okka
Williams, Laura
Butler, John S.
Byrne, Niall
Molloy, Fiona
Moore, Helena
Healy, Daniel G.
Lynch, Tim
Edwards, Mark J.
Walsh, Cathal
Reilly, Richard B.
O'Riordan, Sean
Hutchinson, Michael
Publication Title: 
Psychiatry and Clinical Neurosciences

This review provides a broad overview of the state of research in the genetics of anxiety disorders (AD). Genetic epidemiological studies report a moderate level of familial aggregation (odds ratio: 4-6) and heritability estimates are about 30-50%. Twin studies suggest that the genetic architecture of AD is not isomorphic with their classifications, sharing risk factors with each other. So far, linkage and association studies of AD have produced inconclusive results. Genome-wide association studies of AD can provide an unbiased survey of common genetic variations across the entire genome.

Shimada-Sugimoto, Mihoko
Otowa, Takeshi
Hettema, John M.


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