Publication Title: 
Nature Cell Biology

The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 (silent information regulator 2) regulates gene silencing in yeast and promotes lifespan extension during caloric restriction. The mammalian homologue of Sir2 (SirT1) regulates p53, NF-kappaB and Forkhead transcription factors, and is implicated in stress response. This report shows that the cell-cycle and apoptosis regulator E2F1 induces SirT1 expression at the transcriptional level. Furthermore, SirT1 binds to E2F1 and inhibits E2F1 activities, forming a negative feedback loop.

Wang, Chuangui
Chen, Lihong
Hou, Xinghua
Li, Zhenyu
Kabra, Neha
Ma, Yihong
Nemoto, Shino
Finkel, Toren
Gu, Wei
Cress, W. Douglas
Chen, Jiandong
Publication Title: 
Science (New York, N.Y.)

Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a "BH3-domain-only" BCL-2 family member, triggers the homooligomerization of "multidomain" conserved proapoptotic family members BAK or BAX, resulting in the release of cytochrome c from mitochondria. We find that cells lacking both Bax and Bak, but not cells lacking only one of these components, are completely resistant to tBID-induced cytochrome c release and apoptosis.

Wei, M. C.
Zong, W. X.
Cheng, E. H.
Lindsten, T.
Panoutsakopoulou, V.
Ross, A. J.
Roth, K. A.
MacGregor, G. R.
Thompson, C. B.
Korsmeyer, S. J.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the immunoregulation and short-term therapeutic effects of super-selective intra-arterial chemotherapy combined with Fuzheng Kang'ai Granules, a compound Chinese herbal medicine, on patients with late gastric cancer. METHODS: Forty patients with late gastric antrum cancer were randomly divided into study group and control group.

Zhu, Jin-Shui
Song, Ming-Quan
Wang, Long
Sun, Qun
Zhu, Li
Fang, Chun
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