Exodeoxyribonucleases

Publication Title: 
Mechanisms of Ageing and Development

The phenomenon that caloric restriction increases life span in a variety of species from yeast to mice has been the focus of much interest. Recent observations suggest that a protein important for heterochromatin formation, Sir2, is central for caloric restriction-induced longevity in lower organisms.

Author(s): 
Hasty, P.
Publication Title: 
Aging Clinical and Experimental Research
Author(s): 
Butler, Robert N.
Warner, Huber R.
Williams, T. Franklin
Austad, Steven N.
Brody, Jacob A.
Campisi, Judith
Cerami, Anthony
Cohen, Gene
Cristofalo, Vincent J.
Drachman, David A.
Finch, Caleb E.
Fridovich, Irwin
Harley, Calvin B.
Havlik, Richard J.
Martin, George M.
Miller, Richard A.
Olshansky, S. Jay
Pereira-Smith, Olivia M.
Smith, James R.
Sprott, Richard L.
West, Michael D.
Wilmoth, John R.
Wright, Woodring E.
Publication Title: 
FEBS letters

Caloric restriction (CR) is known to promote longevity in various species. Sirtuin-mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein (WRN), a recognized DNA repair protein. In addition, CR simultaneously increased the level of SIRT1, a mammalian sirtuin. In HEK293T cells, sirtuin inhibitors decreased the WRN level, and this effect was suppressed by proteasomal inhibitors. Furthermore, we found a decrease in the WRN level in Sirt1-deficient mice.

Author(s): 
Kahyo, Tomoaki
Mostoslavsky, Raul
Goto, Makoto
Setou, Mitsutoshi
Publication Title: 
FEBS letters

Caloric restriction (CR) is known to promote longevity in various species. Sirtuin-mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein (WRN), a recognized DNA repair protein. In addition, CR simultaneously increased the level of SIRT1, a mammalian sirtuin. In HEK293T cells, sirtuin inhibitors decreased the WRN level, and this effect was suppressed by proteasomal inhibitors. Furthermore, we found a decrease in the WRN level in Sirt1-deficient mice.

Author(s): 
Kahyo, Tomoaki
Mostoslavsky, Raul
Goto, Makoto
Setou, Mitsutoshi
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