Publication Title: 
Phytotherapy research: PTR

Associations of plants have been widely used, for centuries, in Ayurveda and in Chinese medicine and have been increasingly acknowledged in Western medicine. The objective of this study is to assess the level of toxicity of an association of three plants: Crataegus oxyacantha, Passiflora incarnata, and Valeriana officinalis (CPV extract). This association was administered to rats, mice, and dogs, both acute and chronically for 180 days. The tests used in the acute experiments were: observational pharmacological screening, LD(50), motor coordination and motor activity.

Tabach, Ricardo
Rodrigues, Eliana
Carlini, E. A.
Publication Title: 
The Journal of Sexual Medicine

INTRODUCTION: Human estrus is a new topic to discussion. Articles related to this are few. AIM: Authors present here the first known report on human estrus, which was discussed in the Ayurveda classic text, Susruta Samhita, dated back to the 1st century BC. MAIN OUTCOME MEASURE: Supporting this, evidence from modern literature is presented here. RESULTS: Estrus discussed as a fresh topic. CONCLUSION: Authors concluded that all modern research results, though limited, are in support of the oldest writing about human estrus.

Skandhan, Kalanghot Padmanabhan
Rajahariprasad, Achuthan
Sumangala, Balakrishnan
Publication Title: 
PloS One

BACKGROUND: Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies.

Dwivedi, Vibha
Anandan, E. M.
Mony, Rajesh S.
Muraleedharan, T. S.
Valiathan, M. S.
Mutsuddi, Mousumi
Lakhotia, Subhash C.
Publication Title: 
Ancok, D.
Publication Title: 
Social Science & Medicine (1982)

The present study explored symptoms, attitudes and treatments surrounding women's health and menopause among the Q'eqchi Maya of the eastern tropical lowlands of Guatemala. Data were obtained through participant observation, semi-structured interviews, focus groups and plant walks with 50 Q'eqchi community members from the state of Izabal, Municipality of Livingston, including five midwives, five traditional male healers and eight postmenopausal women.

Michel, Joanna L.
Mahady, Gail B.
Veliz, Mario
Soejarto, Doel D.
Cáceres, Armando
Publication Title: 
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

The prevalence of type 2 diabetes (T2DM) is increasing, creating a need for T2DM animal models for the study of disease pathogenesis, prevention, and treatment. The purpose of this project was to develop a rat model of T2DM that more closely models the pathophysiology of T2DM in humans. The model was created by crossing obese Sprague-Dawley rats with insulin resistance resulting from polygenic adult-onset obesity with Zucker diabetic fatty-lean rats that have a defect in pancreatic beta-cell function but normal leptin signaling.

Cummings, Bethany P.
Digitale, Erin K.
Stanhope, Kimber L.
Graham, James L.
Baskin, Denis G.
Reed, Benjamin J.
Sweet, Ian R.
Griffen, Steven C.
Havel, Peter J.
Publication Title: 
Fertility and Sterility

OBJECTIVE: To examine the theoretical and methodologic rationales for the use of sham acupuncture controls in trials of adjuvant acupuncture for in vitro fertilization (IVF), and to identify the drawbacks of using a sham acupuncture control that may have its own effects on the pregnancy outcome. BACKGROUND: Acupuncture has typically been tested in trials that evaluate subjective, patient-reported outcomes such as pain. Ratings of pain and similar subjective states can be strongly influenced by respondents' prejudgments, preferences, and expectations about treatment benefits.

Manheimer, Eric
Publication Title: 
Reproductive Toxicology (Elmsford, N.Y.)

There is now considerable interest in the intestinally derived soy isoflavone metabolite, equol, which occurs in the enantiomeric forms, S-(-)equol and R-(+)equol, both differing in biological actions. Little is known about effects of either enantiomer on reproductive development, yet such knowledge is fundamental because of the recent commercialization of S-(-)equol as a dietary supplement. S-(-)equol and R-(+)equol were therefore investigated to determine their effects on reproductive development and fertility in the Sprague-Dawley rat.

Brown, Nadine M.
Lindley, Stephanie L.
Witte, David P.
Setchell, Kenneth D. R.
Publication Title: 

Although the effectiveness of nuclear hormone-receptor complexes is known to depend on coregulator partner proteins, relatively little is known about the roles of coregulators in uterine development and early stages of pregnancy and implantation.

Park, Sunghee
Yoon, Sangyeon
Zhao, Yuechao
Park, Seong-Eun
Liao, Lan
Xu, Jianming
Lydon, John P.
DeMayo, Francesco J.
O'Malley, Bert W.
Bagchi, Milan K.
Katzenellenbogen, Benita S.
Publication Title: 
BMC ecology

BACKGROUND: The free-living nematode Caenorhabditis elegans is the predominant model organism in biological research, being used by a huge number of laboratories worldwide. Many researchers have evaluated life-history traits of C. elegans in investigations covering quite different aspects such as ecotoxicology, inbreeding depression and heterosis, dietary restriction/supplement, mutations, and ageing.

Muschiol, Daniel
Schroeder, Fabian
Traunspurger, Walter


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