Genes, p16

Publication Title: 
Cancer Research

Inactivation of p16INK4 tumor suppressor gene function is frequently observed in breast cancer. We examined p16INK4 expression in human mammary epithelial cell (HMEC) cultures established from four normal donors. Normal HMECs divide a limited number of times before proliferation ceases in a state referred to as selection (or M0). The cell subpopulation that emerges spontaneously from selection undergoes a further limited period of proliferation before senescence.

Huschtscha, L. I.
Noble, J. R.
Neumann, A. A.
Moy, E. L.
Barry, P.
Melki, J. R.
Clark, S. J.
Reddel, R. R.
Publication Title: 

Replicative senescence is thought to be a significant barrier to human tumorigenesis, which in human fibroblasts, and many other cell types, can be overcome experimentally by combined loss of function of p53 and Rb 'pathways'. To avoid the confounding pleiotropic effects of HPVE7 frequently used in such studies, here we have employed retroviral vectors over-expressing CDK4 or CDK6 as a more representative model of naturally-occurring mutations targeting the Rb pathway.

Morris, Mark
Hepburn, Peter
Wynford-Thomas, David
Publication Title: 
Experimental and Molecular Pathology

Melanoma is a highly aggressive cancer, accounting for up to 75% of skin cancer deaths. A small proportion of melanoma cases can be ascribed to the presence of highly penetrant germline mutations, and approximately 40% of hereditary melanoma cases are caused by CDKN2A mutations. The current study sought to investigate whether the presence of germline CDKN2A mutations or the occurrence of cutaneous melanoma would result in constitutive genome-wide DNA methylation changes.

de Ara˙jo, …rica Sara Souza
Marchi, Fabio Albuquerque
Rodrigues, Tatiane Cristina
Vieira, Henrique Cursino
Kuasne, Hellen
Achatz, Maria Isabel Waddington
Moredo, Luciana Facure
de S·, Bianca Costa Soares
Duprat, Jo„o Pereira
Brentani, Helena Paula
Rosenberg, Carla
Carraro, Dirce Maria
Krepischi, Ana Cristina Victorino
Publication Title: 
Biological & Pharmaceutical Bulletin

Colla corii asini (E'jiao), donkey-hide gelatin prepared by stewing and concentrating from Equus asinus L. donkey hide, is a traditional Chinese medicine preparation widely used in clinical hematic antanemic therapy in China. The aim of the present study was to investigate potential anti-aging effect of Colla corii asini and explore related mechanisms in D-galactose (gal) induced aging model mice. The mice were artificially induced aging by subcutaneously injection with D-gal at the dose of 100 mg/kg·d for 8 weeks.

Wang, Dongliang
Liu, Maoxuan
Cao, Jichao
Cheng, Yanna
Zhuo, Chen
Xu, Hongyan
Tian, Shousheng
Zhang, Yan
Zhang, Jian
Wang, Fengshan
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