Genetic Testing

Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Ayurveda, India's natural health care tradition, has a unique way of classifying human population based on individual constitution or prakriti. Ayurveda's tridosha theory identifies principles of motion (vata), metabolism (pitta), and structure (kapha) as discrete phenotypic groupings. Patwardhan et al.

Author(s): 
Patwardhan, Bhushan
Bodeker, Gerard
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Correlating phenotypes with genotypes remains the major postgenomic challenge. Attempts to correlate phenotype characteristics associated with ethnicity, geographical divisions, or diseases to genotypes have had limited success. This means that current approaches for identifying phenotypes associated with haplotypes may be inadequate. OBJECTIVES: We hypothesize that a human phenome based on Ayurveda could provide an appropriate approach. Specifically, there could be a genetic basis for the three major constitutions (Prakriti) described in Ayurveda.

Author(s): 
Bhushan, Patwardhan
Kalpana, Joshi
Arvind, Chopra
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Ayurveda, India's natural health care tradition, has a unique way of classifying human population based on individual constitution or prakriti. Ayurveda's tridosha theory identifies principles of motion (vata), metabolism (pitta), and structure (kapha) as discrete phenotypic groupings. Patwardhan et al.

Author(s): 
Patwardhan, Bhushan
Bodeker, Gerard
Publication Title: 
Archives of Neurology

OBJECTIVE: To study the effect of familial Alzheimer disease (FAD) mutations and APOE genotype on plasma signaling protein levels. DESIGN: Cross-sectional comparison of plasma levels of 77 proteins measured using multiplex immune assays. SETTING: A tertiary referral dementia research center. PARTICIPANTS: Thirty-three persons from families harboring PSEN1 or APP mutations, aged 19 to 59 years. MAIN OUTCOME MEASURES: Protein levels were compared between FAD mutation carriers (MCs) and noncarriers (NCs) and among APOE genotype groups, using multiple linear regression models.

Author(s): 
Ringman, John M.
Elashoff, David
Geschwind, Daniel H.
Welsh, Brian T.
Gylys, Karen H.
Lee, Cathy
Cummings, Jeffrey L.
Cole, Greg M.
Publication Title: 
Oncology Nursing Forum

PURPOSE/OBJECTIVES: To examine breast and ovarian cancer screening and risk-reducing behaviors of women seeking genetic cancer risk assessment (GCRA). DESIGN: Descriptive, cross-sectional. SETTING: An insurance-based clinic that serves high-risk patients in a southern California cancer center. SAMPLE: 134 women with breast or ovarian cancer (affected group) and 80 women with a family history of breast or ovarian cancer (unaffected group). The mean age of the sample was 48 years (range = 21-86), 79% were Caucasian, 66% were married, 60% were college educated, and 78% had children.

Author(s): 
MacDonald, Deborah J.
Sarna, Linda
Uman, Gwen C.
Grant, Marcia
Weitzel, Jeffrey N.
Publication Title: 
Annual Review of Genomics and Human Genetics

The existing research base on public attitudes about genetics shows that people's attitudes vary according to the specific technologies and purposes to which genetic knowledge is applied. Genetic testing is viewed highly favorably, genetically modified food is viewed with ambivalence, and cloning is viewed negatively. Attitudes are favorable for uses that maintain a perceived natural order and unfavorable for uses that are perceived to change it.

Author(s): 
Condit, Celeste M.
Publication Title: 
Diabetes

Weight loss in response to caloric restriction is variable. Because skeletal muscle mitochondrial proton leak may account for a large proportion of resting metabolic rate, we compared proton leak in diet-resistant and diet-responsive overweight women and compared the expression and gene characteristics of uncoupling protein (UCP)2 and UCP3. Of 1,129 overweight women who completed the University of Ottawa Weight Management Clinic program, 353 met compliance criteria and were free of medical conditions that could affect weight loss.

Author(s): 
Harper, Mary-Ellen
Dent, Robert
Monemdjou, Shadi
Bézaire, Véronic
Van Wyck, Lloyd
Wells, George
Kavaslar, Gul Nihan
Gauthier, Andre
Tesson, Frédérique
McPherson, Ruth
Publication Title: 
Neurology

BACKGROUND: Carnitine palmitoyltransferase II (CPT II) deficiency is an important cause of recurrent rhabdomyolysis in children and adults. Current treatment includes dietary fat restriction, with increased carbohydrate intake and exercise restriction to avoid muscle pain and rhabdomyolysis. METHODS: CPT II enzyme assay, DNA mutation analysis, quantitative analysis of acylcarnitines in blood and cultured fibroblasts, urinary organic acids, the standardized 36-item Short-Form Health Status survey (SF-36) version 2, and bioelectric impedance for body fat composition.

Author(s): 
Roe, C. R.
Yang, B.-Z.
Brunengraber, H.
Roe, D. S.
Wallace, M.
Garritson, B. K.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Ayurveda, India's natural health care tradition, has a unique way of classifying human population based on individual constitution or prakriti. Ayurveda's tridosha theory identifies principles of motion (vata), metabolism (pitta), and structure (kapha) as discrete phenotypic groupings. Patwardhan et al.

Author(s): 
Patwardhan, Bhushan
Bodeker, Gerard

Pages

Subscribe to RSS - Genetic Testing