Glioblastoma

Publication Title: 
Neuro-Oncology

BACKGROUND: A proportion of glioblastoma stemlike cells (GSCs) expressing endothelial cell marker CDH5 (vascular-endothelial-cadherin or CD144) can transdifferentiate into endothelial cells and form blood vessels. However, the implications of CDH5 expression in gliomas and how it is regulated in GSCs remain to be clarified. METHODS: The mRNA and protein levels of CDH5 were detected in glioma samples and cultured cell lines, and the prognostic value of the CDH5 expression level for GBM patients was evaluated.

Author(s): 
Mao, Xing-Gang
Xue, Xiao-Yan
Wang, Liang
Zhang, Xiang
Yan, Ming
Tu, Yan-yang
Lin, Wei
Jiang, Xiao-Fan
Ren, Hong-Gang
Zhang, Wei
Song, Shao-Jun
Publication Title: 
Revue Neurologique
Author(s): 
Bouteille, M.
Houdart, R.
Delarue, G.
Publication Title: 
PloS One

Glioblastomas are the most aggressive primary brain tumors and their heterogeneity and complexity often renders them non responsive to various conventional treatments. Search for herbal products having potential anti-cancer activity is an active area of research in the Indian traditional system of medicine i.e., Ayurveda. Tinospora cordifolia, also named as 'heavenly elixir' is used in various ayurvedic decoctions as panacea to treat several body ailments.

Author(s): 
Mishra, Rachana
Kaur, Gurcharan
Publication Title: 
Cancer Science

Ashwagandha (Withania somnifera) is widely used in the Indian traditional system of medicine, Ayurveda. Although it is claimed to have a large variety of health-promoting effects, including therapeutic effects on stress and disease, the mechanisms of action have not yet been determined. In the present study, we aimed to investigate the growth inhibition and differentiation potential of the alcoholic extract of Ashwagandha leaves (i-Extract), its different constituents (Withaferin A, Withanone, Withanolide A) and their combinations on glioma (C6 and YKG1) cell lines.

Author(s): 
Shah, Navjot
Kataria, Hardeep
Kaul, Sunil C.
Ishii, Tetsuro
Kaur, Gurcharan
Wadhwa, Renu
Publication Title: 
PloS One

Glioblastomas are the most aggressive primary brain tumors and their heterogeneity and complexity often renders them non responsive to various conventional treatments. Search for herbal products having potential anti-cancer activity is an active area of research in the Indian traditional system of medicine i.e., Ayurveda. Tinospora cordifolia, also named as 'heavenly elixir' is used in various ayurvedic decoctions as panacea to treat several body ailments.

Author(s): 
Mishra, Rachana
Kaur, Gurcharan
Publication Title: 
Anticancer Research

BACKGROUND/AIM: Zeng Sheng Ping (ZSP) is a traditional herbal remedy used to prevent progression and growth of neoplastic lesions. It has been shown to inhibit Notch2 expression in a murine lung cancer model, leading us to investigate its therapeutic potential in Notch-dependent brain tumors.

Author(s): 
Lim, Kah Jing
Rajan, Kda
Eberhart, Charles G.
Publication Title: 
Cell

Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation. Tumor cells exploit this pathway to adapt to nutrient deprivation by reactivating the AMPK-eEF2K axis. Adaptation of transformed cells to nutrient withdrawal is severely compromised in cells lacking eEF2K.

Author(s): 
Leprivier, Gabriel
Remke, Marc
Rotblat, Barak
Dubuc, Adrian
Mateo, Abigail-Rachele F.
Kool, Marcel
Agnihotri, Sameer
El-Naggar, Amal
Yu, Bin
Somasekharan, Syam Prakash
Faubert, Brandon
Bridon, Gaëlle
Tognon, Cristina E.
Mathers, Joan
Thomas, Ryan
Li, Amy
Barokas, Adi
Kwok, Brian
Bowden, Mary
Smith, Stephanie
Wu, Xiaochong
Korshunov, Andrey
Hielscher, Thomas
Northcott, Paul A.
Galpin, Jason D.
Ahern, Christopher A.
Wang, Ye
McCabe, Martin G.
Collins, V. Peter
Jones, Russell G.
Pollak, Michael
Delattre, Olivier
Gleave, Martin E.
Jan, Eric
Pfister, Stefan M.
Proud, Christopher G.
Derry, W. Brent
Taylor, Michael D.
Sorensen, Poul H.
Publication Title: 
PloS One

Glioblastoma stem cells (GSC) are a significant cell model for explaining brain tumor recurrence. However, mechanisms underlying their radiochemoresistance remain obscure. Here we show that most clonogenic cells in GSC cultures are sensitive to radiation treatment (RT) with or without temozolomide (TMZ). Only a few single cells survive treatment and regain their self-repopulating capacity.

Author(s): 
Ye, Fei
Zhang, Yibei
Liu, Yue
Yamada, Kazunari
Tso, Jonathan L.
Menjivar, Jimmy C.
Tian, Jane Y.
Yong, William H.
Schaue, Dörthe
Mischel, Paul S.
Cloughesy, Timothy F.
Nelson, Stanley F.
Liau, Linda M.
McBride, William
Tso, Cho-Lea
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: In this study, we have examined the antitumor effects of chloroform extract of Angelica sinensis (AS-C), a traditional Chinese medicine, on glioblastoma multiforme (GBM) brain tumors in vitro and in vivo. EXPERIMENTAL DESIGN: In vitro, GBM cells were treated with AS-C, and the cell proliferation, changes in distributions of cell cycle, and apoptosis were determined. In vivo, human DBTRG-05MG and rat RG2 GBM tumor cells were injected s.c. or i.c. and were treated with AS-C.

Author(s): 
Tsai, Nu-Man
Lin, Shinn-Zong
Lee, Chau-Chin
Chen, Shee-Ping
Su, Hsuan-Chi
Chang, Wen-Liang
Harn, Horng-Jyh
Publication Title: 
Integrative Cancer Therapies

The development of nontoxic agents that can selectively enhance the cytotoxicity of chemotherapy is an important aim in oncology. This study evaluates the ability of infrasound exposure to sensitize glioblastoma cells to cisplatin-induced apoptosis. The infrasound was delivered using a device designed to replicate the unique infrasound emissions measured during external Qigong treatments. Human glioblastoma cell lines harboring wild-type p53 (U87) or mutant p53 (U251, SF210, and SF188) were treated in culture with cisplatin, infrasound emissions, or the combination of the 2 agents.

Author(s): 
Rachlin, Kenneth
Moore, Dan H.
Yount, Garret

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