Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)

Publication Title: 
Cell

Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here, we report that increased synthesis of N-glycan precursors in the hexosamine pathway improves ER protein homeostasis and extends lifespan in C. elegans.

Author(s): 
Denzel, Martin S.
Storm, Nadia J.
Gutschmidt, Aljona
Baddi, Ruth
Hinze, Yvonne
Jarosch, Ernst
Sommer, Thomas
Hoppe, Thorsten
Antebi, Adam
Publication Title: 
Cell

The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.

Author(s): 
Vincenz, Lisa
Hartl, F. Ulrich
Publication Title: 
Cell

Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here, we report that increased synthesis of N-glycan precursors in the hexosamine pathway improves ER protein homeostasis and extends lifespan in C. elegans.

Author(s): 
Denzel, Martin S.
Storm, Nadia J.
Gutschmidt, Aljona
Baddi, Ruth
Hinze, Yvonne
Jarosch, Ernst
Sommer, Thomas
Hoppe, Thorsten
Antebi, Adam
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