Growth Inhibitors

Publication Title: 
Forschende Komplementarmedizin Und Klassische Naturheilkunde = Research in Complementary and Natural Classical Medicine

BACKGROUND: Independent replications of preclinical investigations of homeopathic potencies are rare. However, they are a necessary tool to determine the relevant factors modulating the effects of homeopathic potencies in preclinical systems. OBJECTIVE: The goal of the present study was to reproduce a trial published in 1997. An Italian group of researchers investigated the effect of Arsenicum album 45x on the growth of wheat which had been previously poisoned with a material dose of Arsenicum album.

Author(s): 
Binder, Mascha
Baumgartner, Stephan
Thurneysen, André
Publication Title: 
Journal of Food Protection

The growth-inhibitory activity of materials derived from the fruit of Terminalia chebula was evaluated against six intestinal bacteria by means of an impregnated paper disk agar diffusion method. The butanol fraction of T. chebula extract had profound growth-inhibitory activity at a concentration of 5 mg per disk. The biologically active component isolated from the T. chebula fruits was identified with a variety of spectroscopic analyses as ethanedioic acid. The growth responses varied in accordance with the bacterial strain, chemical, and dosage tested.

Author(s): 
Kim, H. G.
Cho, J. H.
Jeong, E. Y.
Lim, J. H.
Lee, S. H.
Lee, H. S.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Acetyl-11-keto-beta-boswellic acid (AKBA), a component of an Ayurvedic therapeutic plant Boswellia serrata, is a pentacyclic terpenoid active against a large number of inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and bronchial asthma, but the mechanism is poorly understood.

Author(s): 
Takada, Yasunari
Ichikawa, Haruyo
Badmaev, Vladimir
Aggarwal, Bharat B.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Acetyl-11-keto-beta-boswellic acid (AKBA), a component of an Ayurvedic therapeutic plant Boswellia serrata, is a pentacyclic terpenoid active against a large number of inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and bronchial asthma, but the mechanism is poorly understood.

Author(s): 
Takada, Yasunari
Ichikawa, Haruyo
Badmaev, Vladimir
Aggarwal, Bharat B.
Publication Title: 
Journal of Ethnopharmacology

AIMS OF THE STUDY: Achyranthes aspera (Family: Amaranthacea) is a medicinal plant used as an anti-cancer agent in ayurveda, a traditional system of medicine practiced in subcontinental India. The aim of the study was to systematically investigate the anti-proliferative properties of Achyranthes aspera leaves extracted in methanol (LE) on human cancer cells in vitro. MATERIALS AND METHODS: We tested time, dose dependent and specific anti-proliferative activity of LE by clonogenic cell survival assay on human cancer and normal epithelial cell lines in vitro.

Author(s): 
Subbarayan, Pochi R.
Sarkar, Malancha
Impellizzeri, Stefania
Raymo, Francisco
Lokeshwar, Balakrishna L.
Kumar, Pradeep
Agarwal, Ram P.
Ardalan, Bach
Publication Title: 
Cancer Research

PC-SPES is a mixture of eight herbs with antiproliferative activity in prostate cancer cell lines and antitumor effects in animal models of prostate cancer. In addition, evidence of clinical efficacy in advanced prostate cancer has been reported. PC-SPES has also been shown to have antitumor activity against several other cancer cell lines including breast and neuroepithelial cancer, melanoma, and leukemia cell lines.

Author(s): 
Huerta, Sergio
Arteaga, James R.
Irwin, Ronald W.
Ikezoe, Takayuki
Heber, David
Koeffler, H. Phillip
Publication Title: 
Biological & Pharmaceutical Bulletin

Panax ginseng roots, including the steamed roots, have been demonstrated to possess anticancer properties. However, there have been limited published studies on the cancer preventive effects of American ginseng. In this study, the in vitro and in vivo anti-colorectal cancer effects of American ginseng berry extracts, and their representative bioactive compounds were evaluated. The ginsenoside content in unsteamed American ginseng berry extract (AGE) and steamed berry extract (S-AGE) were determined by HPLC.

Author(s): 
Xie, Jing-Tian
Wang, Chong-Zhi
Zhang, Bin
Mehendale, Sangeeta Ram
Li, Xiao-Li
Sun, Shi
Han, Aung Htun
Du, Wei
He, Tong-Chuan
Yuan, Chun-Su
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Immunosuppressive signaling via the A2A adenosine receptor (A2AR) provokes a mechanism that protects inflamed tissues from excessive damage by immune cells. This mechanism is desirable not only for preventing uncontrolled tissue destruction by overactive immune responses, but also for protecting tumor tissues from antitumor immune responses. In aforementioned circumstances, T cell priming may occur in an environment containing high concentrations of extracellular adenosine.

Author(s): 
Ohta, Akio
Ohta, Akiko
Madasu, Manasa
Kini, Radhika
Subramanian, Meenakshi
Goel, Nipun
Sitkovsky, Michail
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Multiple TLR agonists have been shown to have antitumor effects in animal models. However, the therapeutic efficacy of TLR agonist monotherapy in cancer treatment has been limited, and the mechanisms of failure remain unknown. We demonstrate that topical treatment with a TLR-7 agonist, imiquimod, can elicit significant regression of spontaneous breast cancers in neu transgenic mice, a model of human HER-2/neu(+) breast cancer. However, tumor growth progressed once imiquimod therapy was ended.

Author(s): 
Lu, Hailing
Wagner, Wolfgang M.
Gad, Ekram
Yang, Yi
Duan, Hangjun
Amon, Lynn M.
Van Denend, Nathaniel
Larson, Emily R.
Chang, Amy
Tufvesson, Helena
Disis, Mary L.
Publication Title: 
Forschende Komplementärmedizin Und Klassische Naturheilkunde = Research in Complementary and Natural Classical Medicine

BACKGROUND: Most criticism of homeopathy concerns the lack of scientific bases and theoretical models. Fundamental research could make important contributions to our understanding of the mechanisms of action of homeopathic treatments. Plant-based bioassays are suitable for basic research -- lacking the placebo effect and ensuring large data samples for structured statistical analyses.

Author(s): 
Brizzi, Maurizio
Lazzarato, Lisa
Nani, Daniele
Borghini, Francesco
Peruzzi, Maurizio
Betti, Lucietta

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