Guinea Pigs

Publication Title: 
Drugs Under Experimental and Clinical Research

Allergic rhinitis, also known as hay fever, rose fever or summer catarrh, is a major challenge to health professionals. A large number of the world's population, including approximately 40 million Americans, suffers from allergic rhinitis. A novel, botanical formulation (Aller-7) has been developed for the treatment of allergic rhinitis using a combination of extracts from seven medicinal plants, including Phyllanthus emblica, Terminalia chebula, T. bellerica, Albizia lebbeck, Piper nigrum, Zingiber officinale and P. longum, which have a proven history of efficacy and health benefits.

Author(s): 
Amit, A.
Saxena, V. S.
Pratibha, N.
D'Souza, P.
Bagchi, M.
Bagchi, D.
Stohs, S. J.
Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

BACKGROUND: Tri-sa-maw recipe is comprised ofequal proportions of three herbal fruits, including Terminalia chebula Retz., Terminalia sp. and Terminalia bellirica Roxb. The traditional use of this recipe has been reported as a medication for fever; expectorant, relief of tightness in the stomach, laxative and antidiarrheal agent. OBJECTIVE: To study the effects of Tri-sa-maw recipe extract on gastrointestinal tract in both in vitro and in vivo.

Author(s): 
Wannasiri, Supaporn
Jaijoy, Kanjana
Chiranthanut, Natthakarn
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Publication Title: 
Nature

The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30?years. This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole rat. In comparison, a similarly sized house mouse has a maximum lifespan of 4?years. In addition to their longevity, naked mole rats show an unusual resistance to cancer. Multi-year observations of large naked mole-rat colonies did not detect a single incidence of cancer.

Author(s): 
Tian, Xiao
Azpurua, Jorge
Hine, Christopher
Vaidya, Amita
Myakishev-Rempel, Max
Ablaeva, Julia
Mao, Zhiyong
Nevo, Eviatar
Gorbunova, Vera
Seluanov, Andrei
Publication Title: 
Nature

The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30?years. This is the longest reported lifespan for a rodent species and is especially striking considering the small body mass of the naked mole rat. In comparison, a similarly sized house mouse has a maximum lifespan of 4?years. In addition to their longevity, naked mole rats show an unusual resistance to cancer. Multi-year observations of large naked mole-rat colonies did not detect a single incidence of cancer.

Author(s): 
Tian, Xiao
Azpurua, Jorge
Hine, Christopher
Vaidya, Amita
Myakishev-Rempel, Max
Ablaeva, Julia
Mao, Zhiyong
Nevo, Eviatar
Gorbunova, Vera
Seluanov, Andrei
Publication Title: 
Revista Brasileira De Biologia
Author(s): 
Consoli, R. A.
Publication Title: 
Journal of Neuropsychiatry
Author(s): 
Liberson, W. T.
Bernsohn, J.
Wilson, A.
Daly, V.
Publication Title: 
Psychosomatic Medicine
Author(s): 
Freeman, E. H.
Feingold, B. F.
Schlesinger, K.
Gorman, F. J.
Publication Title: 
The American Journal of Clinical Hypnosis
Author(s): 
Kunin, R. A.
Publication Title: 
Archives Internationales De Pharmacodynamie Et De Thérapie

Etomidate, R-(+)-ethyl-1-(1-phenylethyl)-1H-imidazole-5-carboxylate was found to be a potent, short-acting and safe hypnotic; when given intravenously in single doses to mice, rats, guinea-pigs, rabbits and dogs. In rats of different body weight (50, 100, 200 and 300 g) two injection rates were used (2 sec and 2 min). By rapid iv injection in rats of 200 g etomidate (ED50 equal to 0.57 mg/kg) is about 6 times more potent than methohexital (ED50 equal to 3.51 mg/kg) and 25 times more potent than propanidid and thiopental (ED50's equal to 13.4 mg/kg).

Author(s): 
Janssen, P. A.
Niemegeers, C. J.
Marsboom, R. P.
Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

Pharmacological effects of ifenprodil (IP), 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol-L-(+)-tartrate monohydrate (Funai Pharmaceutical), a potential vasodilator, were studied in the dog, rabbit, guinea-pig and mouse. 1) Intravenous administration of IP (0.1 approximately 1 mg/kg) exhibited a continuous fall in blood pressure, an increase in heart rate and an increase in cardiac contractile force in the dog. The depressor and chronotropic effects of IP appeared likewise in the pithed dog, and the depressor responses were slightly more evident in the rabbit.

Author(s): 
Maeda, Y.
Furukawa, T.

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