Hyperbaric Oxygenation

Publication Title: 
Aktuelle Urologie

The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder. New suggestions for definitions and nomenclature take this into consideration. Since aetiology and pathogenesis are still unknown a treatment of the cause is still not possible. There are neither evidence-based treatment algorithms nor a so-called standard therapy. Numerous therapeutic approaches have been tried up to now. These attempts can be divided into oral, intravesical, surgical and physical procedures.

Author(s): 
Binder, I.
Rossbach, G.
van Ophoven, A.
Publication Title: 
Aktuelle Urologie

The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder. New suggestions for definitions and nomenclature take this into consideration. Since aetiology and pathogenesis are still unknown a treatment of the cause is still not possible. There are neither evidence-based treatment algorithms nor a so-called standard therapy. Numerous therapeutic approaches have been tried up to now. These attempts can be divided into oral, intravesical, surgical and physical procedures.

Author(s): 
Binder, I.
Rossbach, G.
van Ophoven, A.
Publication Title: 
Current Pain and Headache Reports

Nonpharmacologic treatment of migraine is often used by patients and can provide interesting options for physicians. Knowledge about the evidence and its absence is important. Avoidance of trigger factors can help, if individualized. Behavioral approaches, such as relaxation techniques, biofeedback, and cognitive-behavioral therapy, require far more specialist time or technical devices, but are supported by some evidence, which is mostly old. The same is true for hypnosis. A new approach in migraine prevention is aerobic exercise, which is associated with positive side effects.

Author(s): 
Sándor, Peter S.
Afra, Judit
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

We hypothesized that elevated partial pressures of O(2) would increase perivascular nitric oxide (*NO) synthesis. Rodents with O(2)- and.NO-specific microelectrodes implanted adjacent to the abdominal aorta were exposed to O(2) at partial pressures from 0.2 to 2.8 atmospheres absolute (ATA). Exposures to 2.0 and 2.8 ATA O(2) stimulated neuronal (type I) NO synthase (nNOS) and significantly increased steady-state.NO concentration, but the mechanism for enzyme activation differed at each partial pressure.

Author(s): 
Thom, Stephen R.
Fisher, Donald
Zhang, Jie
Bhopale, Veena M.
Ohnishi, S. Tsuyoshi
Kotake, Yashige
Ohnishi, Tomoko
Buerk, Donald G.
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

We hypothesized that exposure to hyperbaric oxygen (HBO(2)) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (*NO) -dependent mechanism. The population of CD34(+) cells in the peripheral circulation of humans doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) O(2) for 2 h. Over a course of 20 treatments, circulating CD34(+) cells increased eightfold, although the overall circulating white cell count was not significantly increased. The number of colony-forming cells (CFCs) increased from 16 +/- 2 to 26 +/- 3 CFCs/100,000 monocytes plated.

Author(s): 
Thom, Stephen R.
Bhopale, Veena M.
Velazquez, Omaida C.
Goldstein, Lee J.
Thom, Lynne H.
Buerk, Donald G.
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Accumulating evidence suggests that hyperbaric oxygen (HBO) stimulates neuronal nitric oxide (NO) synthase (NOS) activity, but the influence on endothelial NOS (eNOS) activity and vascular NO bioavailability remains unclear. We used a bioassay employing rat aortic rings to evaluate vascular NO bioavailability. HBO exposure to 2.8 atm absolute (ATA) in vitro decreased ACh relaxation.

Author(s): 
Hink, Jonas
Thom, Stephen R.
Simonsen, Ulf
Rubin, Inger
Jansen, Erik
Publication Title: 
Brain Research

Earlier research has demonstrated that hyperbaric oxygen (HBO2) can produce an antinociceptive effect in models of acute pain. Recent studies have revealed that HBO2 can produce pain relief in animal models of chronic pain as well. The purpose of the present investigation was to ascertain whether HBO2 treatment might suppress allodynia in rats with neuropathic pain and whether this effect might be blocked by the opioid antagonist naltrexone (NTX).

Author(s): 
Gibbons, Carlee R.
Liu, Shulin
Zhang, Yangmiao
Sayre, Casey L.
Levitch, Briana R.
Moehlmann, Sarah B.
Shirachi, Donald Y.
Quock, Raymond M.
Publication Title: 
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia: 1952)

The paper summarizes experience in treating 306 patients with progressive muscular dystrophy during different phases of the disease. The treatment was made with due consideration for a disturbed protein metabolism, a decreased permeability of the membrane in muscular filaments, a normalization of the metabolic product supply from the blood, improvement of the blood flow and cardio-vascular and respiratory insufficiency.

Author(s): 
Badalian, L. O.
Dunaevskaia, G. N.
Sitnikov, V. F.
Publication Title: 
European Journal of Ophthalmology

We describe the results of early hyperbaric oxygenation combined with nifedipine treatment for central retinal artery occlusion, and explain the results pathophysiologically. We report four cases in which hyperbaric oxygenation therapy was applied in combination with nifedipine, eyeball massage, and glycerol for the treatment of central retinal artery occlusion.

Author(s): 
Beiran, I.
Reissman, P.
Scharf, J.
Nahum, Z.
Miller, B.
Publication Title: 
Der Ophthalmologe: Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

Retinal artery occlusion (RAO) is an ophthalmological emergency that causes a major decrease of visual parameters in most of the cases. Purpose of this pilot study was to evaluate the effect of adjunctive hyperbaric oxygen therapy (HBO) on visual acuity (VA). PATIENTS AND METHODS: Patients with acute central or branch artery occlusion (CRAO/BRAO) consecutively admitted to our hospital were offered adjunctive HBO. Standard therapy consisted of ocular massage for 3 minutes, paracentesis and intravenous acetazolamide. HBO (3 x 30 minutes at 240 kPa) was applied t.i.d. on the first day, b.i.d.

Author(s): 
Aisenbrey, S.
Krott, R.
Heller, R.
Krauss, D.
Rössler, G.
Heimann, K.

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