Immunity, Cellular

Publication Title: 
Annals of the New York Academy of Sciences

Mindfulness meditation represents a mental training framework for cultivating the state of mindful awareness in daily life. Recently, there has been a surge of interest in how mindfulness meditation improves human health and well-being. Although studies have shown that mindfulness meditation can improve self-reported measures of disease symptomatology, the effect that mindfulness meditation has on biological mechanisms underlying human aging and disease is less clear.

Black, David S.
Slavich, George M.
Publication Title: 
Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association

This article reviews evidence for the hypothesis that psychological interventions can modulate the immune response in humans and presents a series of models depicting the psychobiological pathways through which this might occur. Although more than 85 trials have been conducted, meta-analyses reveal only modest evidence that interventions can reliably alter immune parameters. The most consistent evidence emerges from hypnosis and conditioning trials. Disclosure and stress management show scattered evidence of success. Relaxation demonstrates little capacity to elicit immune change.

Miller, G. E.
Cohen, S.
Publication Title: 
Journal of Ethnopharmacology

The activity of a crude extract formulation was evaluated in experimental amoebic liver abscess in golden hamsters and in immunomodulation studies. The formulation comprises the following five plants-Boerhavia diffusa, Tinospora cordifolia, Berberis aristata, Terminalia chebula and Zingiber officinale. The formulation had a maximum cure rate of 73% at a dose of 800 mg/kg/day in hepatic amoebiasis reducing the average degree of infection (ADI) to 1.3 as compared to 4.2 for sham-treated controls.

Sohni, Y. R.
Bhatt, R. M.
Publication Title: 
Molecular and Cellular Biochemistry

Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) on noise-stress induced alterations in the antioxidant status and on the cell-mediated immune response in Wistar strain male albino rats. Noise-stress employed in this study was 100 dB for 4 h/d/15 days and Triphala was used at a dose of 1 g/kg/b.w/48 days.

Srikumar, Ramasundaram
Parthasarathy, Narayanaperumal Jeya
Manikandan, Sundaramagalingam
Narayanan, Govindarajulu Sathya
Sheeladevi, Rathinasamy
Publication Title: 
Tijdschrift Voor Gerontologie En Geriatrie

Ageing in immune reactivity is described at the level of lymphoid cells, at that of lymphoid organs and organ function, and at that of regulation of cell and organ function. Apart from shifts in numbers of lymphoid cell subpopulations, the decrease in communication capacity between lymphoid cell populations and in binding of invaders (like bacteria) is an important aspect of ageing. These aspects may contribute to the decreased immune reactivity to invaders and the enhanced incidence of immune reactions to self-components (autoimmune reactivity).

Schuurman, H. J.
Lokhorst, H. M.
Publication Title: 
Age (Dordrecht, Netherlands)

Throughout life, there is an aging of the immune system that causes impairment of its defense capability. Prevention or delay of this deterioration is considered crucial to maintain general health and increase longevity. We evaluated whether dietary supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 could enhance the immune response in the elderly. This multi-center, double-blind, and placebo controlled study enrolled 61 elderly volunteers who were randomly assigned to receive either placebo or probiotics. Each capsule of probiotics contained at least 3?◊?10(7)? L.

Moro-GarcÌa, Marco Antonio
Alonso-Arias, Rebeca
Baltadjieva, Maria
Fern·ndez BenÌtez, Carlos
Fern·ndez Barrial, Manuel Amadeo
DÌaz Ruis·nchez, Enrique
Alonso Santos, Ricardo
Alvarez S·nchez, Magdalena
Saavedra Mij·n, Juan
LÛpez-Larrea, Carlos
Publication Title: 
Age (Dordrecht, Netherlands)

The low percentages of naÔve T cells commonly observed in elderly people are thought to be causally associated with mortality, primarily from infectious disease, and are taken as a hallmark of "immunosenescence". Whether low levels of naive cells actually do associate with mortality has, however, not been tested in longitudinal studies. Here, we present correlations between peripheral T-cell phenotypes and 8-year survival in individuals from the population-based prospective Leiden 85-plus Study.

Derhovanessian, Evelyna
Maier, Andrea B.
H‰hnel, Karin
Zelba, Henning
de Craen, Anton J. M.
Roelofs, Helene
Slagboom, Eline P.
Westendorp, Rudi G. J.
Pawelec, Graham
Publication Title: 
Age (Dordrecht, Netherlands)

The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria. Alterations of immunity with advancing age (immunosenescence) have been widely studied in centenarians who are considered a good example of successful aging. In recent years, attention has shifted to centenarian offspring (CO) as a model of people genetically advantaged for healthy aging and longevity.

Buffa, Silvio
PellicanÚ, Mariavaleria
Bulati, Matteo
Martorana, Adriana
Goldeck, David
Caruso, Calogero
Pawelec, Graham
Colonna-Romano, Giuseppina
Publication Title: 
Birth Defects Original Article Series
Makinodan, T.
Publication Title: 
Mechanisms of Ageing and Development

Oxidative damage by free radicals, which is the basis for the free radical theory of aging, has been well investigated within the context of oxidant/antioxidant balance. Age-associated disorders are believed to be associated with the time-dependent shift in the antioxidant/prooxidant balance in favor of oxidative stress. In this brief review, the importance of dietary antioxidant intervention on longevity and age-associated changes in bodily functions and diseases are discussed.

Meydani, M.


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