Immunity, Cellular

Publication Title: 
African Journal of Medicine and Medical Sciences

The efficacy of Stresroak--an Ayurvedic product (India) was tested in cockerel chicks. Eighty day-old chicks were randomly allocated into four groups with 20 birds per group. Group 1 received Stresroak at the recommended dosage of 1 ml/20 birds for 5 days prior to the NDV vaccinations (i/o, LaSota and Komarov). Group 2 received Stresroak at double the recommended dosage prior to vaccinations. Group 3 received no treatment but had all the afore mentioned vaccinations while Group 4 received neither treatments nor vaccinations and therefore served as the control group.

Author(s): 
Sanda, M. E.
Anene, B. M.
Owoade, A. A.
Publication Title: 
Vaccine

Withania somnifera (Ashwagandha) is a plant with known ethnomedicinal properties and its use in Ayurvedic medicine in India is well documented. The present investigation reports on immunomodulatory efficacy of aqueous-ethanol extracts of roots of three selected Withania somnifera chemotypes designated as NMITLI 101R, NMITLI 118R and NMITLI 128R. Each chemotype was administered 10-100 mg/kg orally to BALB/c mice once daily for 14 days.

Author(s): 
Kushwaha, Susheela
Roy, Saptarshi
Maity, Rita
Mallick, Asish
Soni, Vishal K.
Singh, Prashant K.
Chaurasiya, Narayan D.
Sangwan, Rajender S.
Misra-Bhattacharya, Shailja
Mandal, Chitra
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Barleria prionitis Linn. (Family: Acanthaceae), one of the important Ayurvedic medicinal plant in India, has long been used to treat variety of ailments including swellings, gout, arthritic and rheumatic disorders, nervine and skin diseases, and also acts as immunorestorative. AIM OF THE STUDY: The present study was aimed to explore in vitro and in vivo immunomodulatory activities of the iridoids fraction i.e. n-butanol fraction of methanol extract from Barleria prionitis aerial parts (IFBp).

Author(s): 
Ghule, B. V.
Yeole, P. G.
Publication Title: 
Immunopharmacology and Immunotoxicology

CONTEXT: Leptadenia reticulata Linn. (Asclpiadaceae) commonly known as "dodi," is an Indian medicinal plant which is known to have ethno-medical uses such as stimulant, tonic, immunostimulant and is one of the ingredient in ayurvedic formulation called as "Chawanprash," which is widely used in India to increase the strength of immune system. OBJECTIVE: The aim of present study is to evaluate immunomodulatory and antioxidant activity of ethanolic extract of L. reticulata L. leaves in rodents.

Author(s): 
Pravansha, S.
Thippeswamy, B. S.
Veerapur, V. P.
Publication Title: 
International Immunopharmacology

Mesua ferrea L. (Nagkesar) is traditionally being used for antiseptic, anti-inflammatory, antiasthmatic and antiallergic activities. It is an ingredient of ayurvedic formulations like Brahma Rasayana and Chyavanprash which are being used to improve immunity. The present study was performed to evaluate immunomodulatory activity of mesuol isolated from M. ferrea seed oil in experimental animals.

Author(s): 
Chahar, Manoj Kumar
Sanjaya Kumar, D. S.
Lokesh, T.
Manohara, K. P.
Publication Title: 
International Immunopharmacology

Aged people are more prone to developing neurodegenerative and infectious diseases, autoimmune disorders, and cancer due to impairment of neuroendocrine-immune functions. Neuronal degeneration and immunosuppression aided by increased generation of reactive oxygen species combined with loss of antioxidant enzyme activities promote the aging process. Bacopa monnieri (brahmi), an Ayurvedic herb, and donepezil, a reversible acetylcholinesterase inhibitor, have been used to reverse cognitive dysfunctions in several neurodegenerative diseases.

Author(s): 
Priyanka, Hannah P.
Singh, Ran Vijay
Mishra, Miti
ThyagaRajan, Srinivasan
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Two VLA proteins (or beta 1 integrins; originally called very late activation antigens) that bind to distinct determinants on fibronectin (FN) are increased on activated immune or memory T cells. VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.

Author(s): 
Ferguson, T. A.
Mizutani, H.
Kupper, T. S.
Publication Title: 
Clinical and Diagnostic Laboratory Immunology

Traditional herbal formulas used to treat inflammatory arthritis in China and India include Boswellia carterii or Boswellia serrata. They both contain boswellic acids (BAs) which have been shown to exhibit anti-inflammatory and antiarthritic properties. This study tests the hypothesis that mixtures of BAs derived from B. carterii have immunomodulatory properties. B.

Author(s): 
Chevrier, Marc R.
Ryan, Abigail E.
Lee, David Y.-W.
Zhongze, Ma
Wu-Yan, Zhang
Via, Charles S.
Publication Title: 
Cell Death and Differentiation

Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and maintain immunity and tolerance. DCs initiate immune responses in a manner that depends on signals they receive from pathogens, surrounding cells and their products. Most tumors are infiltrated by DCs. Thus, interactions between DCs and dying tumor cells may determine the balance between immunity and tolerance to tumor cells. In addition, DCs also display non-immunologic effects on tumors and the tumor microenvironment.

Author(s): 
Dhodapkar, M. V.
Dhodapkar, K. M.
Palucka, A. K.
Publication Title: 
Glia

Steroidal estrogens can regulate inflammatory immune responses and may be involved in the suppression of multiple sclerosis (MS) during pregnancy. However, the risks and side effects associated with steroidal estrogens may limit their usefulness for long-term MS therapy. Selective estrogen receptor modulators (SERMs) could provide an alternative therapeutic strategy, because they behave as estrogen agonists in some tissues, but are either inert or behave like estrogen antagonists in other tissues.

Author(s): 
Bebo, Bruce F.
Dehghani, Babak
Foster, Scott
Kurniawan, Astrid
Lopez, Francisco J.
Sherman, Larry S.

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