INDEL Mutation

Publication Title: 
Molecular Biology and Evolution

Insertions or deletions (indels) of amino acids residues have been recognized as an important source of genetic and structural divergence between paralogous Bcl-2 family members. However, these signature sequences have not so far been extensively investigated amongst orthologous Bcl-2 family proteins. Bcl2l10 is an antiapoptotic member of the Bcl-2 family that has evolved rapidly throughout the vertebrate lineage and which shows conserved abundant expression in eggs and oocytes.

Author(s): 
Guillemin, Yannis
Cornut-Thibaut, AurÈlie
Gillet, Germain
Penin, FranÁois
Aouacheria, Abdel
Publication Title: 
BMC genomics

BACKGROUND: Classical and quantitative linkage analyses of genetic crosses have traditionally been used to map genes of interest, such as those conferring chloroquine or quinine resistance in malaria parasites. Next-generation sequencing technologies now present the possibility of determining genome-wide genetic variation at single base-pair resolution. Here, we combine in vivo experimental evolution, a rapid genetic strategy and whole genome re-sequencing to identify the precise genetic basis of artemisinin resistance in a lineage of the rodent malaria parasite, Plasmodium chabaudi.

Author(s): 
Hunt, Paul
Martinelli, Axel
Modrzynska, Katarzyna
Borges, Sofia
Creasey, Alison
Rodrigues, Louise
Beraldi, Dario
Loewe, Laurence
Fawcett, Richard
Kumar, Sujai
Thomson, Marian
Trivedi, Urmi
Otto, Thomas D.
Pain, Arnab
Blaxter, Mark
Cravo, Pedro
Publication Title: 
Antimicrobial Agents and Chemotherapy

Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for the multidrug resistance protein (MRP) type of ABC transporters: Pfmrp1, previously associated with decreased parasite drug susceptibility, and the poorly studied Pfmrp2.

Author(s): 
Veiga, Maria Isabel
Osório, Nuno S.
Ferreira, Pedro Eduardo
Franzén, Oscar
Dahlstrom, Sabina
Lum, J. Koji
Nosten, François
Gil, José Pedro
Publication Title: 
Molecular Biology and Evolution

Although it belongs to the order Carnivora, the giant panda is a vegetarian with 99% of its diet being bamboo. The draft genome sequence of the giant panda shows that its umami taste receptor gene Tas1r1 is a pseudogene, prompting the proposal that the loss of the umami perception explains why the giant panda is herbivorous. To test this hypothesis, we sequenced all six exons of Tas1r1 in another individual of the giant panda and five other carnivores. We found that the open reading frame (ORF) of Tas1r1 is intact in all these carnivores except the giant panda.

Author(s): 
Zhao, Huabin
Yang, Jian-Rong
Xu, Huailiang
Zhang, Jianzhi
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