Interleukin-8

Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Helicobacter pylori infection is associated with gastritis, peptic ulcer, and gastric cancer. Due to its high global prevalence and uprising resistance to available antibiotics, efforts are now directed to identify alternative source to treat and prevent associated disorders.

Author(s): 
Zaidi, Syed Faisal
Muhammad, Jibran Sualeh
Shahryar, Saeeda
Usmanghani, Khan
Gilani, Anwarul-Hassan
Jafri, Wasim
Sugiyama, Toshiro
Publication Title: 
Phytotherapy research: PTR

Penta-O-galloyl-?-D-glucose (PGG) occurrs in high concentrations in medicinal herbs such as Rhus chinensis, Paeonia suffruticosa, Acer truncatum and Terminalia chebula, which demonstrate anti-inflammatory activity. We investigated the effect of PGG on stimulated and non-stimulated neutrophils in processes which included reactive oxygen species generation (ROS), metalloproteinase-9 and interleukin-8 secretion (IL-8), ?? integrin (CD11b) and L-selectin (CD62L) expression and apoptosis.

Author(s): 
Kiss, Anna K.
Filipek, Agnieszka
Zy?y?ska-Granica, Barbara
Naruszewicz, Marek
Publication Title: 
Phytotherapy research: PTR

Eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between DNA and NF-kB, a transcription factor involved in the expression of proinflammatory genes. Cystic fibrosis (CF) cell line stimulated by TNF-? has been used as inflammatory cellular model to determinate interleukin-8 (IL-8), one of the most relevant pro-inflammatory mediator in CF regulated by the NF-kB.

Author(s): 
Guerrini, Alessandra
Mancini, Irene
Maietti, Silvia
Rossi, Damiano
Poli, Ferruccio
Sacchetti, Gianni
Gambari, Roberto
Borgatti, Monica
Publication Title: 
Age (Dordrecht, Netherlands)

Throughout life, there is an aging of the immune system that causes impairment of its defense capability. Prevention or delay of this deterioration is considered crucial to maintain general health and increase longevity. We evaluated whether dietary supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 could enhance the immune response in the elderly. This multi-center, double-blind, and placebo controlled study enrolled 61 elderly volunteers who were randomly assigned to receive either placebo or probiotics. Each capsule of probiotics contained at least 3?◊?10(7)? L.

Author(s): 
Moro-GarcÌa, Marco Antonio
Alonso-Arias, Rebeca
Baltadjieva, Maria
Fern·ndez BenÌtez, Carlos
Fern·ndez Barrial, Manuel Amadeo
DÌaz Ruis·nchez, Enrique
Alonso Santos, Ricardo
Alvarez S·nchez, Magdalena
Saavedra Mij·n, Juan
LÛpez-Larrea, Carlos
Publication Title: 
Clinical chemistry and laboratory medicine: CCLM / FESCC

BACKGROUND: Aging is associated with low-grade elevation of circulating inflammatory markers, leading to increased risk of morbidity and mortality. The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects. METHODS: Within the ZINCAGE study, 957 healthy old subjects (>or=60 years old) from five European countries were recruited.

Author(s): 
Dedoussis, George V.
Kanoni, Stavroula
Mariani, Erminia
Cattini, Luca
Herbein, Georges
Fulop, Tamas
Varin, Audrey
Rink, Lothar
Jajte, Jolanta
Monti, Daniela
Marcellini, Fiorela
Malavolta, Marco
Mocchegiani, Eugenio
Publication Title: 
Psychological Medicine

BACKGROUND: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. METHOD: We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ).

Author(s): 
Dennison, U.
McKernan, D.
Cryan, J.
Dinan, T.
Publication Title: 
American Journal of Alzheimer's Disease and Other Dementias

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities. Epigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease. We aimed to detect noninvasive peripheral biomarkers with a high degree of sensitivity and specificity in diagnosis and progression of AD.

Author(s): 
Alsadany, Mohamad A.
Shehata, Hanan H.
Mohamad, Magda I.
Mahfouz, Riham G.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Single doses (250, 500, 1,000, or 2,000 units/kg) of an ovine polyclonal-specific Fab fragment directed against tumor necrosis factor-alpha (TNF-alpha) were given to 17 adult patients with severe falciparum malaria immediately before treatment with artesunate in a pilot study to assess safety and optimal dosage with a view to future studies. Clinical and laboratory variables were compared with 11 controls. In the groups given Fab, there was a tendency for a faster resolution of clinical manifestations and reduction of fever but also a tendency towards longer parasite clearance times.

Author(s): 
Looareesuwan, S.
Sjostrom, L.
Krudsood, S.
Wilairatana, P.
Porter, R. S.
Hills, F.
Warrell, D. A.
Publication Title: 
Phytotherapy research: PTR

Eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between DNA and NF-kB, a transcription factor involved in the expression of proinflammatory genes. Cystic fibrosis (CF) cell line stimulated by TNF-α has been used as inflammatory cellular model to determinate interleukin-8 (IL-8), one of the most relevant pro-inflammatory mediator in CF regulated by the NF-kB.

Author(s): 
Guerrini, Alessandra
Mancini, Irene
Maietti, Silvia
Rossi, Damiano
Poli, Ferruccio
Sacchetti, Gianni
Gambari, Roberto
Borgatti, Monica
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: In addition to being a cardiovascular risk marker, recent studies support a role for CRP in atherothrombosis. Several investigators have reported that CRP binds to Fcgamma receptors on leukocytes. The aim of the study is to determine the processing of CRP by human aortic endothelial cells (HAECs). METHODS AND RESULTS: Binding studies were performed by incubation of HAECs with biotinylated CRP (B-CRP, 25 to 200 microg/mL) for 30 to 180 minutes at 4 degrees C. B-CRP binding was quantitated using streptavidin-fluorescein isothiocyanate followed by flow cytometry.

Author(s): 
Devaraj, Sridevi
Du Clos, Terry W.
Jialal, Ishwarlal

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