Lupus Erythematosus, Systemic

Publication Title: 
The American Journal of Clinical Hypnosis

For many years Western Medicine has considered the immune system to be separate and independent from the central nervous system. However, significant scientific advances and research discoveries that occurred during the past 50 years have presented additional facts that the immune system does interact with the central nervous system with mutual influence. This article provides a systematic review of the literature on the connection between the brain and the immune system and its clinical implications.

Author(s): 
Torem, Moshe S.
Publication Title: 
Zeitschrift Fur Rheumatologie

Seventeen studies were examined with regard to efficacy and scientific quality of acupuncture in rheumatoid arthritis, spondarthropathy, lupus erythematosus, local and progressive systemic scleroderma. Acupuncture cannot be recommended for treatment of these diseases. By far, the most studies examined failed to show sufficient quality.

Author(s): 
Lautenschläger, J.
Publication Title: 
Arthritis Care & Research

OBJECTIVE: Survival of patients with systemic lupus erythematosus (SLE) has significantly improved over the past decades. As SLE patients live longer they inevitably experience a range of clinical manifestations and somatic symptoms. Quality of life may also be impacted through a range of subjective indicators. Among these parameters, fatigue is the most prevalent complaint. Nonpharmacologic strategies seem regularly utilized for fatigue management in SLE; however, their real effects are not known.

Author(s): 
del Pino-Sedeño, Tasmania
Trujillo-Martín, María M.
Ruiz-Irastorza, Guillermo
Cuellar-Pompa, Leticia
de Pascual-Medina, Ana M.
Serrano-Aguilar, Pedro
Spanish Systemic Lupus Erythematosus CPG Development Group
Publication Title: 
Arthritis Research & Therapy

Systemic lupus erythematosus (SLE) is a complex disease characterized by numerous autoantibodies and clinical involvement in multiple organ systems. The immunological events triggering the onset and progression of clinical manifestations are also complex and multi-step, including breach of tolerance in the adaptive immune system, amplification of autoimmunity through innate and adaptive immune system dysregulation, and end-organ damage.

Author(s): 
Marian, Valentin
Anolik, Jennifer H.
Publication Title: 
Lupus

B cells are critical players in the orchestration of properly regulated immune responses, normally providing protective immunity without autoimmunity. Balance in the B cell compartment is achieved through the finely regulated participation of multiple B cell populations with different antibody-dependent and independent functions. Both types of functions allow B cells to modulate other components of the innate and adaptive immune system. Autoantibody-independent B cell functions include antigen presentation, T cell activation and polarization, and dendritic cell modulation.

Author(s): 
Anolik, J. H.
Publication Title: 
BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy

Systemic lupus erythematosus (SLE) is a complex heterogeneous disease, posing challenges to clinical trials. As in other autoimmune diseases, B-lymphocytes play a central role in lupus pathogenesis. The finding that selection and survival of B cells are controlled by a variety of signals, including those provided by the longevity factor BAFF (B-cell activating factor), also called BLyS (B-lymphocyte stimulator), led to preclinical trials that revealed that BAFF represents a promising therapeutic target for human lupus. Belimumab is a fully human monoclonal antibody directed against BAFF.

Author(s): 
Zouali, Moncef
Uy, Eugene A.
Publication Title: 
Journal of Dental Research

Discoveries of immunomodulatory functions in mesenchymal stem cells (MSCs) have suggested that they might have therapeutic utility in treating immune diseases. Recently, a novel MSC population was identified from dental pulp of human supernumerary teeth, and its multipotency characterized. Herein, we first examined the in vitro and in vivo immunomodulatory functions of human supernumerary tooth-derived stem cells (SNTSCs).

Author(s): 
Makino, Y.
Yamaza, H.
Akiyama, K.
Ma, L.
Hoshino, Y.
Nonaka, K.
Terada, Y.
Kukita, T.
Shi, S.
Yamaza, T.
Publication Title: 
Journal of Clinical Pathology
Author(s): 
Marten, R. H.
Blackburn, E. K.
Publication Title: 
A.M.A. Archives of Dermatology
Author(s): 
Marten, R. H.
Blackburn, E. K.
Publication Title: 
Arthritis Care & Research

OBJECTIVE: Individuals with systemic lupus erythematosus (SLE) often experience symptoms that affect family relationships, which are important components of quality of life. To assess the impact of SLE on family role functioning, we developed a 6-domain (Fatigue, Activity participation, Mental health, Isolation, Love and intimacy, and You/fulfilling family roles [FAMILY]) measure. The objectives of this study were to pilot test and achieve preliminary validation for the SLE-FAMILY questionnaire. METHODS: This was a 3-phase study.

Author(s): 
Hassett, Afton L.
Li, Tracy
Radvanski, Diane C.
Savage, Shantal V.
Buyske, Steven
Schiff, Samuel A.
Katz, Patricia P.

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