Machado-Joseph Disease

Publication Title: 
Nature Cell Biology

Protein ubiquitylation is a key post-translational control mechanism contributing to different physiological processes, such as signal transduction and ageing. The size and linkage of a ubiquitin chain, which determines whether a substrate is efficiently targeted for proteasomal degradation, is determined by the interplay between ubiquitylation and deubiquitylation. A conserved factor that orchestrates distinct substrate-processing co-regulators in diverse species is the ubiquitin-selective chaperone CDC-48 (also known as p97).

Author(s): 
Kuhlbrodt, Kirsten
Janiesch, Philipp Christoph
Kevei, …va
Segref, Alexandra
Barikbin, Roja
Hoppe, Thorsten
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