Mammary Neoplasms, Experimental

Publication Title: 
Anticancer Research

BACKGROUND: Artemisinin is a compound isolated from the wormwood Artemisia annua L. It reacts with iron and forms cytotoxic free radicals. It is selectively more toxic to cancer than normal cells because cancer cells contain significantly more intracellular free iron. Previously, we found that covalently tagging artemisinin to transferrin enhanced the selectivity and toxicity of artemisinin toward cancer cells in vitro. In the present research, artemisinin-transferrin conjugate was tested in a rat breast cancer model.

Author(s): 
Lai, Henry
Nakase, Ikuhiko
Lacoste, Eric
Singh, Narendra P.
Sasaki, Tomikazu
Publication Title: 
Iranian Journal of Allergy, Asthma, and Immunology

Recent studies have indicated the profound anti-tumor activity of artemisinin's compounds, among which; arteether is an oil-soluble derivative of artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. An experiment was carried out on tumor-bearing Balb/c mice to estimate the effects of Arteether on tumor growth and antitumor immune responses. Briefly, 6mg/kg/day of Arteether and diluents were administered to two groups of mice. Tumor sizes were measured using digital verniercallipers.

Author(s): 
Azimi Mohamadabadi, Maryam
Hassan, Zuhair Muhammad
Zavaran Hosseini, Ahmad
Noori, Shekoofe
Mahdavi, Mehdi
Maroufizadeh, Saman
Maroof, Hamidreza
Publication Title: 
BMC medicine

BACKGROUND: The mangosteen fruit has a long history of medicinal use in Chinese and Ayurvedic medicine. Recently, the compound α-mangostin, which is isolated from the pericarp of the fruit, was shown to induce cell death in various types of cancer cells in in vitro studies. This led us to investigate the antitumor growth and antimetastatic activities of α-mangostin in an immunocompetent xenograft model of mouse metastatic mammary cancer having a p53 mutation that induces a metastatic spectrum similar to that seen in human breast cancers.

Author(s): 
Shibata, Masa-Aki
Iinuma, Munekazu
Morimoto, Junji
Kurose, Hitomi
Akamatsu, Kanako
Okuno, Yasushi
Akao, Yukihiro
Otsuki, Yoshinori
Publication Title: 
Journal of the National Cancer Institute

BACKGROUND: Efficacy of withaferin A (WA), an Ayurvedic medicine constituent, for prevention of mammary cancer and its associated mechanisms were investigated using mouse mammary tumor virus-neu (MMTV-neu) transgenic model. METHODS: Incidence and burden of mammary cancer and pulmonary metastasis were scored in female MMTV-neu mice after 28 weeks of intraperitoneal administration with 100 µg WA (three times/week) (n = 32) or vehicle (n = 29).

Author(s): 
Hahm, Eun-Ryeong
Lee, Joomin
Kim, Su-Hyeong
Sehrawat, Anuradha
Arlotti, Julie A.
Shiva, Sruti S.
Bhargava, Rohit
Singh, Shivendra V.
Publication Title: 
Pharmacology, Biochemistry, and Behavior

Maharishi-4 (M-4), an ayurvedic food supplement, was tested for anticarcinogenic and anticancer properties against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. The 6% M-4-supplemented diet protected DMBA-induced carcinogenesis by reducing both tumor incidence and multiplicity during initiation and promotion phases. The control animals who developed tumors when supplemented with M-4 diet for four weeks showed tumor regression in 60% of cases.

Author(s): 
Sharma, H. M.
Dwivedi, C.
Satter, B. C.
Gudehithlu, K. P.
Abou-Issa, H.
Malarkey, W.
Tejwani, G. A.
Publication Title: 
Phytotherapy research: PTR

Semecarpus anacardium Linn. of the family Anacardiaceae has many applications in the Ayurvedic and Siddha systems of medicine. We have tested the antitumour activity of Semecarpus anacardium nut extract against experimental mammary carcinoma in animals. As there is a direct relationship between the proliferation of tumour cells and the activities of the glycolytic and gluconeogenic enzymes, we studied changes in the activities of enzymes involved in this metabolic pathway in the liver and kidney.

Author(s): 
Sujatha, Venugopal
Sachdanandam, Panchanatham
Publication Title: 
The Journal of Pharmacy and Pharmacology

Semecarpus anacardium Linn. of the family Anacardiaceae has many applications in the Ayurvedic and Siddha systems of medicine. We have evaluated the effect of S. anacardium nut milk extract on carbohydrate metabolizing enzymes and mitochondrial tricarboxylic acid cycle and respiratory enzymes in liver and kidney mitochondria of dimethyl benzanthracene-induced mammary carcinoma in Sprague-Dawley rats.

Author(s): 
Arathi, G.
Sachdanandam, P.
Publication Title: 
BMC medicine

BACKGROUND: The mangosteen fruit has a long history of medicinal use in Chinese and Ayurvedic medicine. Recently, the compound α-mangostin, which is isolated from the pericarp of the fruit, was shown to induce cell death in various types of cancer cells in in vitro studies. This led us to investigate the antitumor growth and antimetastatic activities of α-mangostin in an immunocompetent xenograft model of mouse metastatic mammary cancer having a p53 mutation that induces a metastatic spectrum similar to that seen in human breast cancers.

Author(s): 
Shibata, Masa-Aki
Iinuma, Munekazu
Morimoto, Junji
Kurose, Hitomi
Akamatsu, Kanako
Okuno, Yasushi
Akao, Yukihiro
Otsuki, Yoshinori
Publication Title: 
Journal of the National Cancer Institute

BACKGROUND: Efficacy of withaferin A (WA), an Ayurvedic medicine constituent, for prevention of mammary cancer and its associated mechanisms were investigated using mouse mammary tumor virus-neu (MMTV-neu) transgenic model. METHODS: Incidence and burden of mammary cancer and pulmonary metastasis were scored in female MMTV-neu mice after 28 weeks of intraperitoneal administration with 100 µg WA (three times/week) (n = 32) or vehicle (n = 29).

Author(s): 
Hahm, Eun-Ryeong
Lee, Joomin
Kim, Su-Hyeong
Sehrawat, Anuradha
Arlotti, Julie A.
Shiva, Sruti S.
Bhargava, Rohit
Singh, Shivendra V.
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Breast cancer is significantly less prevalent among Asian women, whose diets contain high intake of soy products and tea. The objective of our present study was to identify the combined effects of dietary soy phytochemicals and tea components on breast tumor progression in a clinically relevant in vivo model of MCF-7 androgen-dependent human breast tumor in female SCID mice.

Author(s): 
Zhou, Jin-Rong
Yu, Lunyin
Mai, Zhiming
Blackburn, George L.

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