Mental disorder

Publication Title: 
Nutritional Neuroscience

BACKGROUND: Major depressive disorder is a common, chronic condition that imposes a substantial burden of disability globally. As current treatments are estimated to address only one-third of the disease burden of depressive disorders, there is a need for new approaches to prevent depression or to delay its progression. While in its early stages, converging evidence from laboratory, population research, and clinical trials now suggests that dietary patterns and specific dietary factors may influence the risk for depression.

Opie, R. S.
Itsiopoulos, C.
Parletta, N.
Sanchez-Villegas, A.
Akbaraly, T. N.
Ruusunen, A.
Jacka, F. N.
Publication Title: 
Clinical Epigenetics

Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found significant hypomethylation of FAM63B in exon 9. Here, we used iPLEX-based methylation analysis to investigate two CpG sites in FAM63B in blood samples from 459 BD cases and 268 controls. Both sites were significantly hypomethylated in BD cases (lowest p value?=?3.94 ◊ 10(-8)).

Starnawska, Anna
Demontis, Ditte
McQuillin, Andrew
O'Brien, Niamh L.
Staunstrup, Nicklas H.
Mors, Ole
Nielsen, Anders L.
B¯rglum, Anders D.
Nyegaard, Mette
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