Metabolic Syndrome X

Publication Title: 
Alternative Therapies in Health and Medicine

Cardiovascular disease (CVD) is the leading cause of death and disability in the industrialized world, and its prevalence is rapidly increasing among developing nations. The increasing global prevalence of CVD reflects in part the concurrent rise in insulin resistance, obesity, dyslipidemia, and other atherogenic changes associated with insulin resistance syndrome (IRS). Evidence suggests that chronic stress and related psychosocial factors also play an important role in the development and progression of IRS-related states and ultimately, in the pathogenesis of CVD.

Innes, Kim E.
Vincent, Heather K.
Taylor, Ann Gill
Publication Title: 
The Journal of the American Board of Family Practice

OBJECTIVE: To conduct a systematic review of published literature regarding the effects of yoga, a promising mind-body therapy, on specific anthropometric and physiologic indices of cardiovascular disease (CVD) risk and on related clinical endpoints. METHODS: We performed a literature search using 4 computerized English and Indian scientific databases. The search was restricted to original studies (1970 to 2004) evaluating the effects of yoga on CVD or indices of CVD risk associated with the insulin resistance syndrome (IRS).

Innes, Kim E.
Bourguignon, Cheryl
Taylor, Ann Gill
Publication Title: 
European Journal of Preventive Cardiology

BACKGROUND: Yoga, a popular mind-body practice, may produce changes in cardiovascular disease (CVD) and metabolic syndrome risk factors. DESIGN: This was a systematic review and random-effects meta-analysis of randomized controlled trials (RCTs). METHODS: Electronic searches of MEDLINE, EMBASE, CINAHL, PsycINFO, and The Cochrane Central Register of Controlled Trials were performed for systematic reviews and RCTs through December 2013. Studies were included if they were English, peer-reviewed, focused on asana-based yoga in adults, and reported relevant outcomes.

Chu, Paula
Gotink, Rinske A.
Yeh, Gloria Y.
Goldie, Sue J.
Hunink, M. G. Myriam
Publication Title: 
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie

The various mechanisms that may explain the association between brain dysfunction and the pathogenesis of metabolic syndrome (MS) leading to cardiovascular disease and type 2 diabetes have been reviewed. A Medline search was conducted until September 2003, and articles published in various national and international journals were reviewed. Experts working in the field were also consulted.

Singh, Ram B.
Pella, Daniel
Mechirova, Viola
Otsuka, Kuniaki
Publication Title: 
Phytotherapy research: PTR

There is documented evidence of the use of Terminalia chebula for various ailments in the Ayurvedic literature. The extract has been shown to possess glucose lowering activity and to improve insulin sensitivity in animal models of type 2 diabetes mellitus. The present study was carried out to study the dose response relationship of this extract in a rat model of metabolic syndrome. Six groups of rats were fed a high fructose diet (HFD) for a period of 20 days to induce metabolic syndrome. Three doses of fruit extract of T.

Singh, Inderjeet
Singh, Pawan Kumar
Bhansali, Shobhit
Shafiq, Nusrat
Malhotra, Samir
Pandhi, Promila
Pal Singh, Amrit
Publication Title: 
JAMA: the journal of the American Medical Association

CONTEXT: Individuals with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility. OBJECTIVE: To identify specific biological and genetic factors that are associated with or reliably define a human longevity phenotype.

Barzilai, Nir
Atzmon, Gil
Schechter, Clyde
Schaefer, Ernst J.
Cupples, Adrienne L.
Lipton, Richard
Cheng, Suzanne
Shuldiner, Alan R.
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity. DESIGN: Case-control study. SETTING: A university hospital in Leiden, the Netherlands. PARTICIPANTS: One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus. MEASUREMENTS: Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program.

Rozing, Maarten P.
Westendorp, Rudi G. J.
de Craen, Anton J. M.
Frˆlich, Marijke
de Goeij, Moniek C. M.
Heijmans, Bastiaan T.
Beekman, Marian
Wijsman, Carolien A.
Mooijaart, Simon P.
Blauw, Gerard-Jan
Slagboom, P. Eline
van Heemst, Diana
Leiden Longevity Study Group
Publication Title: 

We review the progress in testing the thrifty phenotype hypothesis. Many human epidemiological studies both by ourselves and others have confirmed and extended the original observations on which the hypothesis was based. We are not aware of any contradictory findings and we emphasise the strength of the association between birth weight and the subsequent development of the metabolic syndrome. We have worked extensively experimentally to test the hypothesis in a rat model in which pregnant and/or lactating dams are fed a diet moderately restricted in proteins.

Hales, C. N.
Ozanne, S. E.
Publication Title: 
Trends in Molecular Medicine

Calorie restriction (CR) extends lifespan in a wide variety of species and mitigates diseases of aging in mammals. Here, we describe the evidence that the silent information regulator 2 (SIR2) gene, which encodes a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, regulates lifespan and mediates CR in lower species such as Saccharomyces cerevisiae and Caenorhabditis elegans. We discuss the emerging roles of mammalian SIR2 homologs in regulating physiological changes triggered by CR and their potential connections to diseases of aging.

Chen, Danica
Guarente, Leonard
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Japan has the longest life expectancy in the world. It was an average 85.59 years for women and 78.64 years for men and 77.2 years for women and 71.9 years for men in average health expectancy in 2004. As the diet becomes more westernized, the number of patients with diabetic, cardiovascular, and cerebrovascular diseases due to the metabolic syndrome is increasing. In 2002, our university was selected as a COE21st century participant by the Ministry of Education, Culture, Sports, Science and Technology.

Kinae, Naohide


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