Motor Activity

Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To assess lifestyle factors including physical activity, smoking, alcohol consumption, and dietary habits in men and women with exceptional longevity. DESIGN: Retrospective cohort study. SETTING: A cohort of community-dwelling Ashkenazi Jewish individuals with exceptional longevity defined as survival and living independently at age 95 and older.

Rajpathak, Swapnil N.
Liu, Yingheng
Ben-David, Orit
Reddy, Saritha
Atzmon, Gil
Crandall, Jill
Barzilai, Nir
Publication Title: 
Cell Metabolism

Changes in fat content have been associated with dietary restriction (DR), but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shift their metabolism toward increasing fatty-acid synthesis and breakdown, which is required for various responses to DR. Inhibition of fatty-acid synthesis or oxidation genes specifically in the muscle tissue inhibited life-span extension upon DR. Furthermore, DR enhances spontaneous activity of flies, which was found to be dependent on the enhanced fatty-acid metabolism.

Katewa, Subhash D.
Demontis, Fabio
Kolipinski, Marysia
Hubbard, Alan
Gill, Matthew S.
Perrimon, Norbert
Melov, Simon
Kapahi, Pankaj
Publication Title: 
Biomedical and environmental sciences: BES

Major and profound changes have taken place in China over the past 30 years. Rapid socioeconomic progress has exerted a great impact on lifestyle, ranging from food, clothing, working and living conditions, and means of transportation to leisure activities and entertainment. At the same time, new health problems have emerged, and health services are facing new challenges. Presently, cardiovascular diseases (CVD) are among the top health problems of the Chinese people, and pose a serious challenge to all engaged in the prevention and control of these diseases.

Hu, Sheng Shou
Kong, Ling Zhi
Gao, Run Lin
Zhu, Man Lu
Wang, Wen
Wang, Yong Jun
Wu, Zhao Su
Chen, Wei Wei
Liu, Ming Bo
Editorial Board
Publication Title: 
CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne

BACKGROUND: Increases in life expectancy make it important to remain healthy for as long as possible. Our objective was to examine the extent to which healthy behaviours in midlife, separately and in combination, predict successful aging. METHODS: We used a prospective cohort design involving 5100 men and women aged 42-63 years. Participants were free of cancer, coronary artery disease and stroke when their health behaviours were assessed in 1991-1994 as part of the Whitehall II study. We defined healthy behaviours as never smoking, moderate alcohol consumption, physical activity (?

Sabia, SÈverine
Singh-Manoux, Archana
Hagger-Johnson, Gareth
Cambois, Emmanuelle
Brunner, Eric J.
Kivimaki, Mika
Publication Title: 
Journal of Renal Nutrition: The Official Journal of the Council on Renal Nutrition of the National Kidney Foundation

OBJECTIVES: The aim of this work was to evaluate the correlation between the amount of weekly fish intake and kidney function as measured by creatinine clearance (CCr) rate among elderly inhabitants of Ikaria Island, a place that has been related to an increased rate of longevity. METHODS: From June to October of 2009, 673 males and females, aged 65-100 years and long-term residents of Ikaria Island were enrolled. Of those, 328 (75†±†7 years) were males and 339 (75†±†6 years) were females.

Chrysohoou, Christina
Pitsavos, Christos
Panagiotakos, Demosthenes
Skoumas, John
Lazaros, George
Oikonomou, Evangelos
Galiatsatos, Nikos
Striggou, Marina
Xynogala, Maria
Stefanadis, Christodoulos
Publication Title: 
PloS One

The "organic food" market is the fastest growing food sector, yet it is unclear whether organically raised food is nutritionally superior to conventionally grown food and whether consuming organic food bestows health benefits. In order to evaluate potential health benefits of organic foods, we used the well-characterized fruit fly Drosophila melanogaster as a model system. Fruit flies were raised on a diets consisting of extracts of either conventionally or organically raised produce (bananas, potatoes, raisins, soy beans).

Chhabra, Ria
Kolli, Santharam
Bauer, Johannes H.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: In 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) issued recommendations on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. OBJECTIVE: We investigated whether concordance with WCRF/AICR recommendations is related to risk of death. DESIGN: The current study included 378,864 participants from 9 European countries enrolled in the European Prospective Investigation into Cancer and Nutrition study.

Vergnaud, Anne-Claire
Romaguera, Dora
Peeters, Petra H.
van Gils, Carla H.
Chan, Doris S. M.
Romieu, Isabelle
Freisling, Heinz
Ferrari, Pietro
Clavel-Chapelon, FranÁoise
Fagherazzi, Guy
Dartois, Laureen
Li, Kuanrong
Tikk, Kaja
Bergmann, Manuela M.
Boeing, Heiner
Tj¯nneland, Anne
Olsen, Anja
Overvad, Kim
Dahm, Christina C.
Redondo, Maria Luisa
Agudo, Antonio
S·nchez, MarÌa-JosÈ
Amiano, Pilar
Chirlaque, MarÌa-Dolores
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nick J.
Crowe, Francesca
Trichopoulou, Antonia
Orfanos, Philippos
Trichopoulos, Dimitrios
Masala, Giovanna
Sieri, Sabina
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore
Bueno-de-Mesquita, H. Bas
Ros, Martine M.
May, Anne
Wirf‰lt, Elisabet
Sonestedt, Emily
Johansson, Ingegerd
Hallmans, Gˆran
Lund, Eiliv
Weiderpass, Elisabete
Parr, Christine L.
Riboli, Elio
Norat, Teresa
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Target of rapamycin inhibition by rapamycin feeding has previously been shown to extend life in genetically heterogeneous mice. To examine whether it similarly affected mouse health, we fed encapsulated rapamycin or a control diet to C57BL/6Nia mice of both sexes starting at 19 months of age. We performed a range of health assessments 6 and 12 months later. Rapamycin feeding significantly reduced mTOR activity in most but not all tissues.

Zhang, Yiqiang
Bokov, Alex
Gelfond, John
Soto, Vanessa
Ikeno, Yuji
Hubbard, Gene
Diaz, Vivian
Sloane, Lauren
Maslin, Keith
Treaster, Stephen
RÈndon, Samantha
Van Remmen, Holly
Ward, Walter
Javors, Martin
Richardson, Arlan
Austad, Steven N.
Fischer, Kathleen
Publication Title: 
PloS One

Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL) fed littermates, and all age-matched groups were behaviorally analyzed.

Kuhla, Angela
Lange, Sophie
Holzmann, Carsten
Maass, Fabian
Petersen, Jana
Vollmar, Brigitte
Wree, Andreas
Publication Title: 
Methods in Molecular Biology (Clifton, N.J.)

Drosophila is a genetically tractable system ideal for investigating the mechanisms of aging and developing interventions for promoting healthy aging. Here we describe methods commonly used in Drosophila aging research. These include basic approaches for preparation of diets and measurements of lifespan, food intake, and reproductive output. We also describe some commonly used assays to measure changes in physiological and behavioral functions of Drosophila in aging, such as stress resistance and locomotor activity.

Sun, Yaning
Yolitz, Jason
Wang, Cecilia
Spangler, Edward
Zhan, Ming
Zou, Sige


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