Motor Activity

Publication Title: 
International Journal of Occupational Medicine and Environmental Health

INTRODUCTION: The article presents a selected part of an analysis of health- and lifestyle-related determinants of the longevity of male residents of the city of ?Ûd?. The WHO strategy for the European region assumes that the term' lifestyle' refers to the way of life based on the association between conditions of life understood in a broad sense and individual patterns of behaviour determined by socio-cultural factors and individual features.

Author(s): 
Smigielski, Janusz
Bielecki, Wojciech
Drygas, Wojciech
Publication Title: 
PloS One

Ames dwarf (Prop1 (df/df) ) mice are remarkably long-lived and exhibit many characteristics of delayed aging and extended healthspan. Caloric restriction (CR) has similar effects on healthspan and lifespan, and causes an extension of longevity in Ames dwarf mice. Our study objective was to determine whether Ames dwarfism or CR influence neuromusculoskeletal function in middle-aged (82 ± 12 weeks old) or old (128 ± 14 w.o.) mice.

Author(s): 
Arum, Oge
Rasche, Zachary Andrew
Rickman, Dustin John
Bartke, Andrzej
Publication Title: 
Brain, Behavior, and Immunity

Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency--defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise)--predicts LTL and mitigates previously demonstrated associations between depression diagnosis and LTL.

Author(s): 
Puterman, Eli
Epel, Elissa S.
Lin, Jue
Blackburn, Elizabeth H.
Gross, James J.
Whooley, Mary A.
Cohen, Beth E.
Publication Title: 
PloS One

BACKGROUND: Chronic psychological stress is associated with detrimental effects on physical health, and may operate in part through accelerated cell aging, as indexed by shorter telomeres at the ends of chromosomes. However, not all people under stress have distinctly short telomeres, and we examined whether exercise can serve a stress-buffering function. We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening.

Author(s): 
Puterman, Eli
Lin, Jue
Blackburn, Elizabeth
O'Donovan, Aoife
Adler, Nancy
Epel, Elissa
Publication Title: 
Brain, Behavior, and Immunity

Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency--defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise)--predicts LTL and mitigates previously demonstrated associations between depression diagnosis and LTL.

Author(s): 
Puterman, Eli
Epel, Elissa S.
Lin, Jue
Blackburn, Elizabeth H.
Gross, James J.
Whooley, Mary A.
Cohen, Beth E.
Publication Title: 
Psychosomatic Medicine

OBJECTIVE: Physically active individuals have lower rates of morbidity and mortality, and recent evidence indicates that physical activity may be particularly beneficial to those experiencing chronic stress. The tendency to ruminate increases and prolongs physiological stress responses, including hypothalamic-pituitary-adrenal (HPA) axis responses as indexed by cortisol reactivity to stressful experiences.

Author(s): 
Puterman, Eli
O'Donovan, Aoife
Adler, Nancy E.
Tomiyama, A. Janet
Kemeny, Margaret
Wolkowitz, Owen M.
Epel, Elissa
Publication Title: 
Psychosomatic Medicine

OBJECTIVES: Physical activity and financial strain are independent, and opposite, predictors of disease. This study examines whether physical activity modifies the concurrent and prospective relation between financial strain and impaired fasting glucose. METHODS: Participants were part of the Coronary Artery Risk Development in Young Adults study, a prospective study examining the development of disease. Participants were recruited in 1985 to 1986 and followed up for 20 years. The outcome measures were fasting glucose (FG) levels at Years 7 and 20.

Author(s): 
Puterman, Eli
Adler, Nancy
Matthews, Karen A.
Epel, Elissa
Publication Title: 
PloS One

BACKGROUND: Chronic psychological stress is associated with detrimental effects on physical health, and may operate in part through accelerated cell aging, as indexed by shorter telomeres at the ends of chromosomes. However, not all people under stress have distinctly short telomeres, and we examined whether exercise can serve a stress-buffering function. We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening.

Author(s): 
Puterman, Eli
Lin, Jue
Blackburn, Elizabeth
O'Donovan, Aoife
Adler, Nancy
Epel, Elissa
Publication Title: 
Current Opinion in Clinical Nutrition and Metabolic Care

PURPOSE OF STUDY: To discuss studies in humans and animals revealing the ability of foods to benefit the brain: new information with regards to mechanisms of action and the treatment of neurological and psychiatric disorders. RECENT FINDINGS: Dietary factors exert their effects on the brain by affecting molecular events related to the management of energy metabolism and synaptic plasticity. Energy metabolism influences neuronal function, neuronal signaling, and synaptic plasticity, ultimately affecting mental health.

Author(s): 
Gomez-Pinilla, Fernando
Tyagi, Ethika
Publication Title: 
Psychiatric Genetics

BACKGROUND: Although there is indirect evidence that the effects of antipsychotic drugs may involve modulation of dopamine transmission, their mechanism of action is poorly understood. We hypothesized that antipsychotic drugs mediate their effects by epigenetic modulation. Here, we tested the effect of an antipsychotic, olanzapine, on the DNA methylation status of genes following chronic treatment using rat-specific methylation arrays.

Author(s): 
Melka, Melkaye G.
Rajakumar, Nagalingam
O'Reilly, Richard
Singh, Shiva M.

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