Nerve Tissue Proteins

Publication Title: 
Neuropharmacology

Epigenetic modifications in response to traumatic experience and stress are emerging as important factors in the long-term biological trajectories leading to stress-related psychiatric disorders, reflecting both environmental influences as well as individual genetic predisposition. In particular, recent evidence on DNA methylation changes within distinct genes and pathways but also on a genome-wide level provides new insights into the pathophysiology of stress related psychiatric disorders.

Author(s): 
Klengel, Torsten
Pape, Julius
Binder, Elisabeth B.
Mehta, Divya
Publication Title: 
Neuropharmacology

Alzheimer' s disease (AD) is the most common form of dementia causing an increasing emotional and economical burden to our societies. Although much progress has been made regarding the molecular mechanisms that underlie AD pathogenesis effective therapies are not available yet. The emerging field of neuroepigenetics has provided evidence that de-regulation of epigenetic processes play a role in AD.

Author(s): 
Fischer, Andre
Publication Title: 
Journal of the American Academy of Child and Adolescent Psychiatry

OBJECTIVES: To determine whether epigenetic markers predict dimensional ratings of depression in maltreated children. METHOD: A genome-wide methylation study was completed using the Illumina 450K BeadChip array in 94 maltreated and 96 healthy nontraumatized children with saliva-derived DNA. The 450K BeadChip does not include any methylation sites in the exact location as sites in candidate genes previously examined in the literature, so†a†test†for replication of prior research findings was not feasible.

Author(s): 
Weder, Natalie
Zhang, Huiping
Jensen, Kevin
Yang, Bao Zhu
Simen, Arthur
Jackowski, Andrea
Lipschitz, Deborah
Douglas-Palumberi, Heather
Ge, Margrat
Perepletchikova, Francheska
O'Loughlin, Kerry
Hudziak, James J.
Gelernter, Joel
Kaufman, Joan
Publication Title: 
Genome Biology

BACKGROUND: Although genetic variation is believed to contribute to an individual's susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease. Epigenetics is increasingly believed to play a major role in the development of common clinical phenotypes, including major depressive disorder. RESULTS: Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression.

Author(s): 
Davies, Matthew N.
Krause, Lutz
Bell, Jordana T.
Gao, Fei
Ward, Kirsten J.
Wu, Honglong
Lu, Hanlin
Liu, Yuan
Tsai, Pei-Chein
Collier, David A.
Murphy, Therese
Dempster, Emma
Mill, Jonathan
UK Brain Expression Consortium
Battle, Alexis
Mostafavi, Sara
Zhu, Xiaowei
Henders, Anjali
Byrne, Enda
Wray, Naomi R.
Martin, Nicholas G.
Spector, Tim D.
Wang, Jun
Publication Title: 
Stem Cells Translational Medicine

Recent advances in somatic cell reprogramming have highlighted the plasticity of the somatic epigenome, particularly through demonstrations of direct lineage reprogramming of adult mouse and human fibroblasts to induced pluripotent stem cells (iPSCs) and induced neurons (iNs) under defined conditions. However, human cells appear to be less plastic and have a higher epigenetic hurdle for reprogramming to both iPSCs and iNs. Here, we show that SH2B adaptor protein 1?

Author(s): 
Hsu, Yi-Chao
Chen, Su-Liang
Wang, Ya-Jean
Chen, Yun-Hsiang
Wang, Dan-Yen
Chen, Linyi
Chen, Chia-Hsiang
Chen, Hwei-Hsien
Chiu, Ing-Ming
Publication Title: 
Epigenomics

Huntington's disease is a late-onset, autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric symptomatology. The earliest stage of Huntington's disease is marked by alterations in gene expression, which partially results from dysregulated epigenetic modifications.

Author(s): 
Wang, Fengli
Fischhaber, Paula L.
Guo, Caixia
Tang, Tie-Shan
Publication Title: 
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics

Epigenetic effects on psychiatric traits remain relatively under-studied, and it remains unclear what the sizes of individual epigenetic effects may be, or how they vary between different clinical populations. The gene LRRTM1 (chromosome 2p12) has previously been linked and associated with schizophrenia in a parent-of-origin manner in a set of affected siblings (LOD?=?4.72), indirectly suggesting a disruption of paternal imprinting at this locus in these families.

Author(s): 
Brucato, Nicolas
DeLisi, Lynn E.
Fisher, Simon E.
Francks, Clyde
Publication Title: 
Translational Psychiatry

Epigenetic mechanisms regulate programmed gene expression during prenatal neurogenesis and serve as a mediator between genetics and environment in postnatal life. The recent discovery of 5-hydroxymethylcytosine (5-hmC), with highest concentration in the brain, has added a new dimension to epigenetic regulation of neurogenesis and the development of complex behavior disorders. Here, we take a candidate gene approach to define the role 5-hmC in Engrailed-2 (EN-2) gene expression in the autism cerebellum.

Author(s): 
James, S. J.
Shpyleva, S.
Melnyk, S.
Pavliv, O.
Pogribny, I. P.
Publication Title: 
Neurology

OBJECTIVE: To determine the independent association of the TMEM106B variants with transactive response DNA binding protein 43 (TDP-43) pathology in older persons without frontotemporal lobar degeneration (FTLD) and to explore functional pathways that link the risk variants to the pathology, including a GRN mRNA pathway. METHODS: Data came from 544 autopsied participants without FTLD in 2 community-based studies of aging. Participants underwent uniform neuropathologic evaluations, including TDP-43 cytoplasmic inclusions.

Author(s): 
Yu, Lei
De Jager, Philip L.
Yang, Jingyun
Trojanowski, John Q.
Bennett, David A.
Schneider, Julie A.
Publication Title: 
American Journal of Obstetrics and Gynecology

OBJECTIVE: Autism spectrum disorder (ASD) is associated with preterm birth (PTB), although the reason underlying this relationship is still unclear. Our objective was to examine DNA methylation patterns of 4 ASD candidate genes in human fetal membranes from spontaneous PTB and uncomplicated term birth. STUDY DESIGN: A literature search for genes that have been implicated in ASD yielded 14 candidate genes (OXTR, SHANK3, BCL2, RORA, EN2, RELN, MECP2, AUTS2, NLGN3, NRXN1, SLC6A4, UBE3A, GABA, AFF2) that were epigenetically modified in relation to ASD.

Author(s): 
Behnia, Fara
Parets, Sasha E.
Kechichian, Talar
Yin, Huaizhi
Dutta, Eryn H.
Saade, George R.
Smith, Alicia K.
Menon, Ramkumar

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