No-Observed-Adverse-Effect Level

Publication Title: 
Acta Poloniae Pharmaceutica

The present investigation was an attempt to evaluate the anti-inflammatory effect of a polyherbal preparation (Sudarshanam Oil) on hematological parameters in Wistar rats. This polyherbal formula contains main ingredients of Tinaspora Cordifolia, Curcuma longa, Terminalia chebula, Emblica officinalis, Andrographis paniculata and Terminalia belerica. The active phytochemicals such as tannins, glycosides, flavonoids and triterpenoids are extracted from these herbal plants. And extract was prepared in corn oil.

Author(s): 
Patel, Chintan D.
Modi, Vandana D.
Chakraborty, Bhaswat S.
Mathuria, Neeta
Dadhaniya, Paresh
Borade, Prasad A.
Morankar, Pravin
Publication Title: 
Toxicology Mechanisms and Methods

LI85008F is a novel synergistic composition of Moringa oleifera, Murraya koenigi, and Curcuma longa. These herbs are well recognized and widely used in ayurvedic system of medicine for treating a variety of diseases and are also have been used for culinary purposes for thousands of years. LI85008F inhibits preadipocyte differentiation and potentiates lipid breakdown in mature adipocytes. In diet-induced obese rats, LI85008F significantly reduced weight gain and improved serum adiponectin levels. These findings motivated the authors to determine the broad-spectrum safety of LI85008F.

Author(s): 
Krishnaraju, A. V.
Sundararaju, D.
Srinivas, P.
Rao, C. V.
Sengupta, K.
Trimurtulu, G.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

An Ames test and a 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats were conducted to evaluate the safety of a chicory root extract being investigated as a therapeutic for inflammation. Chicory extract had no mutagenic activity in the Ames test although it was cytotoxic to certain strains of Salmonella at higher doses with and without metabolic activation. For the 28-day rat study, measurements included clinical observations, body weights, food consumption, clinical pathology, gross necropsy and histology.

Author(s): 
Schmidt, Barbara M.
Ilic, Nebojsa
Poulev, Alexander
Raskin, Ilya
Publication Title: 
Toxicologic Pathology

Despite the substantial development and publication of highly reproducible toxicological data, the concept of hormetic dose-response relationships was never integrated into the mainstream of toxicological thought. Review of the historical foundations of the interpretation of the bioassay and assessment of competitive theories of dose-response relationships lead to the conclusion that multiple factors contributed to the marginalization of hormesis during the middle and subsequent decades of the 20th Century.

Author(s): 
Calabrese, E. J.
Baldwin, L. A.
Publication Title: 
Environmental Pollution (Barking, Essex: 1987)

This paper provides an assessment of the toxicological basis of the hormetic dose-response relationship including issues relating to its reproducibility, frequency, and generalizability across biological models, endpoints measured and chemical class/physical stressors and implications for risk assessment. The quantitative features of the hormetic dose response are described and placed within toxicological context that considers study design, temporal assessment, mechanism, and experimental model/population heterogeneity.

Author(s): 
Calabrese, Edward J.
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