Paternal Age

Publication Title: 
Age and Ageing

INTRODUCTION: parental age at conception may affect life expectancy. Adult daughters of older fathers seem to live shorter lives and, in one study, being born to a mother aged <25 was an important predictor of exceptional longevity. The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults. METHODS: in the Canadian Study of Health and Aging (CSHA), data was collected on individuals aged >or=65 using a Self-Assessed Risk Factor Questionnaire and screening interview.

Author(s): 
Hubbard, Ruth E.
Andrew, Melissa K.
Rockwood, Kenneth
Publication Title: 
Biodemography and Social Biology

This study explores the effects of early-life and middle-life conditions on exceptional longevity using two matched case-control studies. The first study compares 198 validated centenarians born in the United States between 1890 and 1893 to their shorter-lived siblings. Family histories of centenarians were reconstructed and exceptional longevity validated using early U.S. censuses, the Social Security Administration Death Master File, state death indexes, online genealogies, and other supplementary data resources.

Author(s): 
Gavrilov, Leonid A.
Gavrilova, Natalia S.
Publication Title: 
Schizophrenia Bulletin

The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat DNA and chromosome breakage have in some cases also been associated with advancing paternal age. Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and schizophrenia.

Author(s): 
Perrin, Mary C.
Brown, Alan S.
Malaspina, Dolores
Publication Title: 
Molecular Psychiatry

Advanced paternal age has been suggested as a risk factor for autism, but empirical evidence is mixed. This study examines whether the association between paternal age and autism in the offspring (1) persists controlling for documented autism risk factors, including family psychiatric history, perinatal conditions, infant characteristics and demographic variables; (2) may be explained by familial traits associated with the autism phenotype, or confounding by parity; and (3) is consistent across epidemiological studies. Multiple study methods were adopted.

Author(s): 
Hultman, C. M.
Sandin, S.
Levine, S. Z.
Lichtenstein, P.
Reichenberg, A.
Publication Title: 
Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics

OBJECTIVE: To investigate whether advanced paternal age is related to an increased risk of schizophrenia in Chinese Han population. METHODS: A case-control design study was performed. Three hundred and fifty-one patients with schizophrenia and 199 unrelated healthy volunteers were recruited. By using Logistic regression, paternal age was divided into five categories, and maternal age into four categories. Setting the paternal age of 26-30 years as reference, the OR, P values and 95% CI of the other paternal age categories were analyzed, respectively.

Author(s): 
Wu, Yue-jing
Liu, Xiang
Zhao, Gao-feng
Ma, Xiao-hong
Li, Tao
Publication Title: 
JAMA psychiatry

IMPORTANCE: Advancing paternal age has been linked to autism. OBJECTIVE: To further expand knowledge about the association between paternal age and autism by studying the effect of grandfathers' age on childhood autism. DESIGN: Population-based, multigenerational, case-control study. SETTING: Nationwide multigeneration and patient registers in Sweden. PARTICIPANTS: We conducted a study of individuals born in Sweden since 1932. Parental age at birth was obtained for more than 90% of the cohort.

Author(s): 
Frans, Emma M.
Sandin, Sven
Reichenberg, Abraham
LÂngstrˆm, Niklas
Lichtenstein, Paul
McGrath, John J.
Hultman, Christina M.
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