Perimenopause

Publication Title: 
Obstetrics and Gynecology

OBJECTIVE: To describe the effects of six interventions for menopausal vasomotor symptoms relative to control in a pooled analysis, facilitating translation of the results for clinicians and symptomatic women. The Menopause Strategies: Finding Lasting Answers for Symptoms and Health network tested these interventions in three randomized clinical trials. METHODS: An analysis of pooled individual-level data from three randomized clinical trials is presented. Participants were 899 perimenopausal and postmenopausal women with at least 14 bothersome vasomotor symptoms per week.

Author(s): 
Guthrie, Katherine A.
LaCroix, Andrea Z.
Ensrud, Kristine E.
Joffe, Hadine
Newton, Katherine M.
Reed, Susan D.
Caan, Bette
Carpenter, Janet S.
Cohen, Lee S.
Freeman, Ellen W.
Larson, Joseph C.
Manson, JoAnn E.
Rexrode, Kathy
Skaar, Todd C.
Sternfeld, Barbara
Anderson, Garnet L.
Publication Title: 
Acupuncture & Electro-Therapeutics Research

Acupuncture has been used for treatment of female reproductive disorders dated back at least 2000 years. It has been known to promote homeostasis, modulate hormonal disturbance and induce ovulation. While the increasing popularity of acupuncture therapy demands a serious debate about its scientific documentation. This article is intended to present the experimental data about the effects of electroacupuncture at Guanyuan (RN 4), bilateral Zhongji (RN 3), Sanyinjiao (SP 6) and bilateral Zigong (EXCA 1) in the ovariectomized rats.

Author(s): 
Zhao, Hong
Chen, Bo-Ying
Publication Title: 
Obstetrics and Gynecology

OBJECTIVE: To examine the association of acupuncture with sleep disturbances and serum sex hormone levels in perimenopausal and postmenopausal women and whether there are associated changes in sex hormone levels. DATA SOURCES: We systematically searched electronic databases (EMBASE, PubMed, PsycINFO, CINAHL, ClinicalTrials.gov, Wanfang Data Chinese Database, and China Knowledge Resource Integrated Database) and the reference lists of the identified studies.

Author(s): 
Chiu, Hsiao-Yean
Hsieh, Yu-Jung
Tsai, Pei-Shan
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: The aim of this study was to conduct a pilot study for the feasibility of planning a definitive clinical trial comparing traditional acupuncture (TA) with sham acupuncture (SA) and waiting control (WC) on menopause-related vasomotor symptoms (VMS), quality of life, and the hypothalamic-pituitary-adrenal axis in perimenopausal and postmenopausal women. METHODS: Thirty-three perimenopausal and postmenopausal women with at least seven VMS daily were randomized to TA, SA, or WC. The TA and SA groups were given three treatments per week for 12 weeks.

Author(s): 
Painovich, Jeannette M.
Shufelt, Chrisandra L.
Azziz, Ricardo
Yang, Yuching
Goodarzi, Mark O.
Braunstein, Glenn D.
Karlan, Beth Y.
Stewart, Paul M.
Merz, C. Noel Bairey
Publication Title: 
Comparative Medicine

Various age-related diseases increase in incidence during perimenopause. However, our understanding of the effects of aging compared with hormonal changes of perimenopause in mediating these disease risks is incomplete, in part due to the lack of an experimental perimenopause model. We therefore aimed to determine whether manipulation of the transition to ovarian failure in rats via the use of 4-vinylcyclohexene diepoxide (VCD) could be used to model and accelerate hormonal changes characteristic of perimenopause.

Author(s): 
Frye, Jennifer B.
Lukefahr, Ashley L.
Wright, Laura E.
Marion, Sam L.
Hoyer, Patricia B.
Funk, Janet L.
Publication Title: 
Trials

BACKGROUND: The perimenopausal period refers to the interval when women's menstrual cycles become irregular and is characterized by an increased risk of depressive symptoms. Use of homeopathy to treat depression is widespread but there is a lack of clinical trials about its efficacy in depression in peri- and postmenopausal women. Previous trials suggest that individualized homeopathic treatments improve depression. In classical homeopathy, an individually selected homeopathic remedy is prescribed after a complete case history of the patient.

Author(s): 
Macías-Cortés, Emma del Carmen
Aguilar-Faisal, Leopoldo
Asbun-Bojalil, Juan
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To compare the distribution characteristics of common syndrome types and syndrome elements of menopause syndrome in perimenopausal and postmenopausal women on the basis of standardized syndrome differentiation extracted by experts' experiences. METHODS: A total of 1 582 outpatients with menopause syndrome who met with the diagnosis and inclusion criteria in seven grade 3 hospitals from October 2006 to June 2007 were included. A clinical epidemiological survey in the patients was carried out.

Author(s): 
Xin, Yi
Wang, Tian-fang
Du, Cai-feng
Li, Li
Ren, Jie
Jin, Zhe
Zhao, Hong
Jing, Yan
Zou, Xiao-Juan
Liu, Hong-Qi
Chen, Ying
Wang, Li-na
Liu, Rui-Fen
Wang, Qing-guo
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: Over the past 5 years, the interest in alternative therapies for menopause has increased dramatically due to the findings of the Women's Health Initiative (U.S. National Institutes of Health). Menoprogen, a traditional Chinese medicine formulation is an herbal remedy that has been used in China for the management of menopause-related symptoms. An observational pilot study was performed to assess the effects of Menoprogen in the management of menopausal symptoms in perimenopausal and postmenopausal women.

Author(s): 
Liu, Daniel
Lu, Ye
Ma, Hong
Wei, Rong-Cheng
Li, Jingrong
Fang, Jin
Mahady, G. B.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

BACKGROUND: As perimenopausal syndrome is a particularly disturbing condition to the patient, it is practical and necessary to establish a program of comprehensive traditional Chinese medicine therapy for women with perimenopausal syndrome. OBJECTIVE: To observe the therapeutic effects of a comprehensive traditional Chinese medicine therapy for women with perimenopausal syndrome in the community. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: Women with perimenopausal syndrome who met the inclusion criteria in 3 communities of Shanghai were selected for this study.

Author(s): 
Zheng, Jin
Li, Ji
Song, Lin-Yi
Ni, Shuang
Chen, Ying-Chao
Huang, Shan-di
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

BACKGROUND: As perimenopausal syndrome is a particularly disturbing condition to the patient, it is practical and necessary to establish a program of comprehensive traditional Chinese medicine therapy for women with perimenopausal syndrome. OBJECTIVE: To observe the therapeutic effects of a comprehensive traditional Chinese medicine therapy for women with perimenopausal syndrome in the community. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: Women with perimenopausal syndrome who met the inclusion criteria in 3 communities of Shanghai were selected for this study.

Author(s): 
Zheng, Jin
Li, Ji
Song, Lin-Yi
Ni, Shuang
Chen, Ying-Chao
Huang, Shan-di

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