Placebo Effect

Publication Title: 
The American Journal of Clinical Hypnosis

Meta-analyses consistently reveal that most of the response to antidepressant treatment can be obtained by placebo, and the difference between response to the drug and the response to any treatment is not clinically significant for most individuals diagnosed with major depressive disorder. Furthermore, the best predictor of antidepressant efficacy is the response to placebo during the so-called placebo run-in period. It can also be shown that a significant portion of the placebo effect is expectancy. These data thus indicate that suggestion is a central factor in treating depression.

Author(s): 
Kirsch, Irving
Low, Carol B.
Publication Title: 
Annali dell'Istituto Superiore Di Sanita

The term "unconventional medicine" refers to a remarkably heterogeneous group of theories and practices (homeopathy, herbal medicine, acupuncture, etc.) different from those peculiar to the dominant health system of a particular society. An unifying characteristic of these practices is that they have not been scientifically tested and that unconventional practitioners largely deny the need for such testing.

Author(s): 
Raschetti, R.
Publication Title: 
Padiatrie Und Padologie

Due to the advance of alternative medicine a critical synopsis by means of the comparison between scientific medicine (clinical medicine) and homeopathy is warranted. The review of studies carried out according to current scientific criteria revealed--at best--a placebo effect of homeopathy. Until now there is no proven mechanism for the mode of action of homeopathy. Sometimes so-called "alternative medicine" prevents effective curative measures.

Author(s): 
Kurz, R.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

In Part I of this pair of articles, the fundamental experimental observations and theoretical perspectives were provided for one to understand the key differences between our normal, uncoupled state of physical reality and the human consciousness-induced coupled state of physical reality.

Author(s): 
Tiller, William A.
Publication Title: 
Bulletin Et Memoires De l'Academie Royale De Medecine De Belgique

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not rely on any scientific basis, it appears to be popular, especially in general practice. The homeopaths have recently taken arguments from a meta-analysis published in 1997 in the Lancet of 89 placebo-controlled trials. This study indeed concluded that the results are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo.

Author(s): 
Scheen, A.
Lefèbvre, P.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: Like other forms of medicine, including Complementary and Alternative Medicine (CAM), homeopathy elicits expectations in patients. The physician-patient relationship, personal and comprehensive treatment and lack of adverse effects are elements in creating positive expectations. Other elements may be associated with negative expectations. METHODS: We conducted a systematic literature review on placebo and nocebo effects in acupuncture and homeopathy using Medline.

Author(s): 
Teixeira, Marcus Z.
Guedes, Cristina H. F. F.
Barreto, Patrícia V.
Martins, Mílton A.
Publication Title: 
Complementary Therapies in Medicine

BACKGROUND: Veterinary homeopathy has led a somewhat shadowy existence since its first introduction. Only in the last three decades has the number of clinical trials increased considerably. This literature is generally not well perceived, which may be partly a consequence of the diffuse and somewhat inaccessible nature of some of the relevant research publications. The Veterinary Clinical Research Database for Homeopathy (VetCR) was launched in 2006 to provide information on existing clinical research in veterinary homeopathy and to facilitate the preparation of systematic reviews.

Author(s): 
Clausen, J.
Albrecht, H.
Mathie, R. T.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

A number of authors have recently discussed the possible role entanglement in homeopathy. Walach et al have published a homeopathic proving which they interpreted as demonstrating entanglement between placebo and verum groups in a proving. The lack of a 'run-in' period was a weakness of this trial. We present further results of our proving of Belladonna which show that subjects who reported symptoms during the placebo run-in period ('presentiment provers') were more likely to report symptoms during the treatment period.

Author(s): 
Lewith, G. T.
Brien, Sarah
Hyland, Michael E.
Publication Title: 
Prescrire International

A meta-analysis published in the Lancet in September 1997 cautiously concluded that homeopathic drug activity is not fully explained by the placebo effect. A thorough examination of this meta-analysis reveals design errors that make the results untrustworthy. There is still nothing to suggest that homeopathic drugs are any more effective than a placebo.

Publication Title: 
Lancet (London, England)

BACKGROUND: Homeopathy seems scientifically implausible, but has widespread use. We aimed to assess whether the clinical effect reported in randomised controlled trials of homeopathic remedies is equivalent to that reported for placebo. METHODS: We sought studies from computerised bibliographies and contracts with researchers, institutions, manufacturers, individual collectors, homeopathic conference proceedings, and books. We included all languages. Double-blind and/or randomised placebo-controlled trials of clinical conditions were considered.

Author(s): 
Linde, K.
Clausius, N.
Ramirez, G.
Melchart, D.
Eitel, F.
Hedges, L. V.
Jonas, W. B.

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