Ploidies

Publication Title: 
The EMBO journal

Senescence is an irreversible cell-cycle arrest that is elicited by a wide range of factors, including replicative exhaustion. Emerging evidences suggest that cellular senescence contributes to ageing and acts as a tumour suppressor mechanism. To identify novel genes regulating senescence, we performed a loss-of-function screen on normal human diploid fibroblasts. We show that downregulation of the AMPK-related protein kinase 5 (ARK5 or NUAK1) results in extension of the cellular replicative lifespan.

Author(s): 
Humbert, Nicolas
Navaratnam, Naveenan
Augert, Arnaud
Da Costa, Marco
Martien, SÈbastien
Wang, Jing
Martinez, Dolores
Abbadie, Corinne
Carling, David
de Launoit, Yvan
Gil, Jesus
Bernard, David
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