Postmenopause

Publication Title: 
Obstetrics and Gynecology

OBJECTIVE: To describe the effects of six interventions for menopausal vasomotor symptoms relative to control in a pooled analysis, facilitating translation of the results for clinicians and symptomatic women. The Menopause Strategies: Finding Lasting Answers for Symptoms and Health network tested these interventions in three randomized clinical trials. METHODS: An analysis of pooled individual-level data from three randomized clinical trials is presented. Participants were 899 perimenopausal and postmenopausal women with at least 14 bothersome vasomotor symptoms per week.

Author(s): 
Guthrie, Katherine A.
LaCroix, Andrea Z.
Ensrud, Kristine E.
Joffe, Hadine
Newton, Katherine M.
Reed, Susan D.
Caan, Bette
Carpenter, Janet S.
Cohen, Lee S.
Freeman, Ellen W.
Larson, Joseph C.
Manson, JoAnn E.
Rexrode, Kathy
Skaar, Todd C.
Sternfeld, Barbara
Anderson, Garnet L.
Publication Title: 
Critical Reviews in Oncology/Hematology

Aromatase Inhibitors (AI) are widely used for the adjuvant treatment of hormone receptor positive breast cancers in the post-menopausal population. AI are often associated with significant joint and muscular symptoms; symptoms that are commonly referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS). AIMSS adversely impacts health-related quality of life of many patients, and reduces AI compliance.

Author(s): 
Roberts, Kate
Rickett, Kirsty
Greer, Ristan
Woodward, Natasha
Publication Title: 
Obstetrics and Gynecology

OBJECTIVE: To examine the association of acupuncture with sleep disturbances and serum sex hormone levels in perimenopausal and postmenopausal women and whether there are associated changes in sex hormone levels. DATA SOURCES: We systematically searched electronic databases (EMBASE, PubMed, PsycINFO, CINAHL, ClinicalTrials.gov, Wanfang Data Chinese Database, and China Knowledge Resource Integrated Database) and the reference lists of the identified studies.

Author(s): 
Chiu, Hsiao-Yean
Hsieh, Yu-Jung
Tsai, Pei-Shan
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

In the first paper to present formal theory explaining that senescence is a consequence of natural selection, W. D. Hamilton concluded that human postmenopausal longevity results from the contributions of ancestral grandmothers to the reproduction of their relatives. A grandmother hypothesis, subsequently elaborated with additional lines of evidence, helps explain both exceptional longevity and additional features of life history that distinguish humans from the other great apes.

Author(s): 
Hawkes, Kristen
Publication Title: 
International Journal of Fertility and Menopausal Studies

There is generally recognized close association between lifestyle and health, even if the exact nature, and importance, of various aspects of the relationship is under investigation, including that between life style and menopause. However, there are abundant and conclusive data showing the positive effect of hormone replacement therapy (HRT) on menopausal symptoms and reduction of long-term menopausal risks. Much is still to be learned, though, about the reciprocal influences of life style, HRT choices, and quality of life.

Author(s): 
Zichella, L.
Publication Title: 
The American Journal of the Medical Sciences

BACKGROUND: Several groups of patients at high risk for cardiovascular disease have been found to show an exaggerated postprandial hypertriglyceridemia. Postprandial lipemia (PPL) therefore has been implicated as a potential additional risk factor that has been evading us. The purpose of this study was to test the effect of high fasting high-density lipoprotein cholesterol (HDL-C) levels on PPL in postmenopausal females.

Author(s): 
Kolovou, Genovef‡ D.
Anagnostopoulou, Katherine K.
Salpea, Klelia D.
Pilatis, Nektarios D.
Iraklianou, Stella
Grapsa, Georgia
Pantelakis, Alexandros
Tsarpalis, Konstantinos
Kapnia, Evaggelia
Cokkinos, Dennis V.
Publication Title: 
Nutrition in Clinical Practice: Official Publication of the American Society for Parenteral and Enteral Nutrition

BACKGROUND: Breast cancer is the most commonly diagnosed cancer among women in the United States. Extensive research has been completed to evaluate the relationship between dietary factors and breast cancer risk and survival after breast cancer; however, a summary report with clinical inference is needed. Materials and METHODS: This review summarizes the current epidemiological and clinical trial evidence relating diet to breast cancer incidence, recurrence, survival, and mortality.

Author(s): 
Thomson, Cynthia A.
Publication Title: 
PloS One

BACKGROUND: A Mediterranean diet has a recognized beneficial effect on health and longevity, with a protective influence on several cancers. However, its association with breast cancer risk remains unclear. OBJECTIVE: We aimed to investigate whether adherence to a Mediterranean dietary pattern influences breast cancer risk. DESIGN: The Swedish Women's Lifestyle and Health cohort study includes 49,258 women aged 30 to 49 years at recruitment in 1991-1992. Consumption of foods and beverages was measured at enrollment using a food frequency questionnaire.

Author(s): 
Couto, Elisabeth
Sandin, Sven
Lˆf, Marie
Ursin, Giske
Adami, Hans-Olov
Weiderpass, Elisabete
Publication Title: 
Brain Research

Longer duration of reproductive years of life and thus greater exposure to endogenous estrogen may be associated with a lower risk of age-related diseases in women. The present study examined the relationship between estimated endogenous estrogen exposure and telomere length (TL) and telomerase activity, two biomarkers of cellular aging, in a sample of postmenopausal women at risk for cognitive decline. Telomere length was measured using a quantitative PCR method and telomerase activity by TRAP (Telomere-Repeats Amplification Protocol) assay in peripheral blood mononuclear cells (PBMCs).

Author(s): 
Lin, Jue
Kroenke, Candyce H.
Epel, Elissa
Kenna, Heather A.
Wolkowitz, Owen M.
Blackburn, Elizabeth
Rasgon, Natalie L.
Publication Title: 
Psychosomatic Medicine

BACKGROUND: Leukocyte telomere shortening can serve as a biomarker of aging, as telomere length (TL) can decline with age and shortening is positively associated with morbidity and mortality. It is therefore important to identify psychological and behavioral factors linked to accelerated telomere shortening. Stress and poorer metabolic health (greater adiposity, insulin resistance, and cortisol) correlate with shorter telomeres.

Author(s): 
Kiefer, Amy
Lin, Jue
Blackburn, Elizabeth
Epel, Elissa

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