Pregnanediones

Publication Title: 
Anaesthesia
Author(s): 
Feldman, S. A.
Robbie, D. S.
Monro, J. A.
Publication Title: 
Minerva Anestesiologica
Author(s): 
Tempo, B.
Berghella, S.
Bernocco, A.
Azzollini, C.
Publication Title: 
European Journal of Pharmacology

Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate (TG41) enhanced the binding both of gamma-aminobutyric acid (GABA) and of flunitrazepam to rat cerebral cortical membranes. Electrophysiological recordings from Xenopus oocytes expressing various recombinant GABA(A) receptor subtypes revealed that TG41 enhanced the function of all receptor subunit combinations tested. The potency of TG41 at receptors containing alpha1, beta2, and gamma2L subunits was greater than that of alphaxalone, etomidate, propofol, or pentobarbital.

Author(s): 
Mascia, Maria Paola
Asproni, Battistina
Busonero, Fabio
Talani, Giuseppe
Maciocco, Elisabetta
Pau, Amedeo
Cerri, Riccardo
Sanna, Enrico
Biggio, Giovanni
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