Protein-Serine-Threonine Kinases

Publication Title: 
Cancer Research

Understanding the molecular basis and target of traditional medicine is critical for drug development. Celastrol, derived from Trypterygium wilfordii Hook F. ("Thunder of God Vine"), a traditional Chinese medicine plant, has been assigned anticancer activities, but its mechanism is not well understood. Here, we investigated whether Celastrol could inhibit angiogenesis-mediated tumor growth and, if so, through what mechanism. When given s.c.

Pang, Xiufeng
Yi, Zhengfang
Zhang, Jing
Lu, Binbin
Sung, Bokyung
Qu, Weijing
Aggarwal, Bharat B.
Liu, Mingyao
Publication Title: 
Molecular Cancer Therapeutics

Artesunate, the active agent from Artemisia annua L. used in the traditional Chinese medicine, is being applied as a first-line drug for malaria treatment, and trials are ongoing that include this drug in cancer therapy. Despite increasing interest in its therapeutic application, the mode of cell killing provoked by artesunate in human cells is unknown. Here, we show that artesunate is a powerful inducer of oxidative DNA damage, giving rise to formamidopyrimidine DNA glycosylase-sensitive sites and the formation of 8-oxoguanine and 1,N6-ethenoadenine.

Berdelle, Nicole
Nikolova, Teodora
Quiros, Steve
Efferth, Thomas
Kaina, Bernd
Publication Title: 
PloS One

AMP-activated protein kinase (AMPK) plays an important role in mediating energy metabolism and is controlled mainly by two upstream kinases, LKB1 or Ca(2+)/calmodulin-dependent protein kinase kinase-β (CaMKKβ). Previously, we found that baicalin, one of the major flavonoids in a traditional Chinese herb medicine, Scutellaria baicalensis, protects against the development of hepatic steatosis in rats feeding with a high-fat diet by the activation of AMPK, but, the underlying mechanism for AMPK activation is unknown.

Ma, Ying
Yang, Fuzhen
Wang, Ying
Du, Zhiyan
Liu, Daihua
Guo, Hongxia
Shen, Jingkang
Peng, Hongli
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The high risk of recurrence faced by patients with bladder cancer has necessitated the administration of supplemental intravesical chemotherapy; however, such treatments often result in severe side effects. As a result, novel intravesical agents with enhanced efficacy and minimal toxicity are urgently required for the treatment of bladder cancer. METHODS: Guizhi Fuling Wan (GFW) is a traditional Chinese medicine shown to inhibit the growth of hepatocellular carcinoma.

Lu, Chi-Chen
Lin, Mei-Yi
Chen, Syue-Yi
Shen, Cheng-Huang
Chen, Lih-Geeng
Hsieh, Hsiao-Yen
Chan, Michael W. Y.
Hsu, Cheng-Da


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