Proteome

Publication Title: 
Journal of Medicinal Food

Terminalia chebula is a native plant from southern Asia to southwestern China that is used in traditional medicine for the treatment of malignant tumors and diabetes. This plant also has antibacterial and immunomodulatory properties. The present study assessed T. chebula extract-dependent protein expression changes in Jurkat cells. Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and Ingenuity Pathways Analysis (IPA) were performed to assess protein expression and networks, respectively. A comparative proteomic profile was determined in T.

Author(s): 
Das, Nando Dulal
Jung, Kyoung Hwa
Park, Ji Hyun
Choi, Mi Ran
Lee, Hyung Tae
Kim, Moo Sung
Lee, Sang Rin
Chai, Young Gyu
Publication Title: 
Mechanisms of Ageing and Development

Caloric restriction (CR) slows the aging process and extends longevity, but the exact underlying mechanisms remain debatable. It has recently been suggested that the beneficial action of CR may be mediated in part by adipose tissue remodeling. Mammals have two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT). In this study, proteome analysis using two-dimensional gel electrophoresis combined with MALDI-TOF MS, and subsequent analyses were performed on both WAT and BAT from 9-month-old male rats fed ad libitum or subjected to CR for 6 months.

Author(s): 
Okita, Naoyuki
Hayashida, Yusuke
Kojima, Yumiko
Fukushima, Mayumi
Yuguchi, Keiko
Mikami, Kentaro
Yamauchi, Akiko
Watanabe, Kyoko
Noguchi, Mituru
Nakamura, Megumi
Toda, Toshifusa
Higami, Yoshikazu
Publication Title: 
Molecular & cellular proteomics: MCP

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be balanced by increasing mitochondrial biogenesis and protein synthesis, resulting in faster protein replacement rates.

Author(s): 
Price, John C.
Khambatta, Cyrus F.
Li, Kelvin W.
Bruss, Matthew D.
Shankaran, Mahalakshmi
Dalidd, Marcy
Floreani, Nicholas A.
Roberts, Lindsay S.
Turner, Scott M.
Holmes, William E.
Hellerstein, Marc K.
Publication Title: 
Current Opinion in Psychiatry

PURPOSE OF REVIEW: This is a review examining recent data from the study of the postmortem central nervous system (CNS) of patients with schizophrenia. RECENT FINDINGS: Studies on the human CNS transcriptome suggest changes in pro-inflammatory pathways and myelination in schizophrenia, whereas changes in the proteome suggest that pathways involved in energy and metabolism may be particularly stressed.

Author(s): 
Dean, Brian
Boer, Simone
Gibbons, Andrew
Money, Tammie
Scarr, Elizabeth
Publication Title: 
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics

In this article, we review studies detailing the correspondence between peripheral blood and brain tissue across various domains of high-throughput -omic analysis in order to provide a context for evaluating blood-based biomarker studies. Specifically, we reviewed seven studies comparing patterns of DNA methylation (i.e., an aspect of the epigenome), eight articles comparing patterns of gene expression (i.e., the transcriptome), and three articles comparing patterns of protein expression (i.e., the proteome).

Author(s): 
Tylee, Daniel S.
Kawaguchi, Daniel M.
Glatt, Stephen J.
Publication Title: 
Biological Psychiatry

Peripheral samples, such as blood and skin, have been used for decades in psychiatric research as surrogates for central nervous system samples. Although the validity of the data obtained from peripheral samples has been questioned and other state-of-the-art techniques, such as human brain imaging, genomics, and induced pluripotent stem cells, seem to reduce the value of peripheral cells, accumulating evidence has suggested that revisiting peripheral samples is worthwhile.

Author(s): 
Hayashi-Takagi, Akiko
Vawter, Marquis P.
Iwamoto, Kazuya
Publication Title: 
Clinical Therapeutics

PURPOSE: This article describes progress to date in the characterization of the salivary epigenome and considers the importance of previous work in the salivary microbiome, proteome, endocrine analytes, genome, and transcriptome. METHODS: PubMed and Web of Science were used to extensively search the existing literature (original research and reviews) related to salivary diagnostics and biomarker development, of which 125 studies were examined.

Author(s): 
Wren, Michael E.
Shirtcliff, Elizabeth A.
Drury, Stacy S.
Publication Title: 
PloS One

Proteome studies contribute markedly to our understanding of parasite biology, host-parasite interactions, and mechanisms of drug action. For most antimalarial drugs neither mode of action nor mechanisms of resistance development are fully elucidated although this would be important prerequisites for successfully developing urgently required novel antimalarials. Here, we establish a large-scale quantitative proteomic approach to examine protein expression changes in trophozoite stages of the malarial parasite Plasmodium falciparum following chloroquine and artemisinin treatment.

Author(s): 
Prieto, Judith Helena
Koncarevic, Sasa
Park, Sung Kyu
Yates, John
Becker, Katja
Publication Title: 
Malaria Journal

BACKGROUND: The emergence of Plasmodium falciparum resistance to most anti-malarial compounds has highlighted the urgency to develop new drugs and to clarify the mechanisms of anti-malarial drugs currently used. Among them, doxycycline is used alone for malaria chemoprophylaxis or in combination with quinine or artemisinin derivatives for malaria treatment. The molecular mechanisms of doxycycline action in P. falciparum have not yet been clearly defined, particularly at the protein level.

Author(s): 
Briolant, Sébastien
Almeras, Lionel
Belghazi, Maya
Boucomont-Chapeaublanc, Elodie
Wurtz, Nathalie
Fontaine, Albin
Granjeaud, Samuel
Fusaï, Thierry
Rogier, Christophe
Pradines, Bruno
Publication Title: 
PloS One

Glandular secreting trichomes (GSTs) are called biofactories because they are active in synthesizing, storing and secreting various types of plant secondary metabolites. As the most effective drug against malaria, artemisinin, a sesquiterpene lactone is derived from GSTs of Artemisia annua. However, low artemisinin content (0.001%~1.54% of dry weight) has hindered its wide application. We investigate the GST-expressed proteins in Artemisia annua using a comparative proteomics approach, aiming for a better understanding of the trichome proteome and arteminisin metabolism.

Author(s): 
Wu, Ting
Wang, Yejun
Guo, Dianjing

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