Publication Title: 
British Journal of Haematology
Ghosh, M. L.
Hudson, G.
Blackburn, E. K.
Publication Title: 
Journal of Cellular Physiology

The visco-elastic behavior of connective tissue is generally attributed to the material properties of the extracellular matrix rather than cellular activity. We have previously shown that fibroblasts within areolar connective tissue exhibit dynamic cytoskeletal remodeling within minutes in response to tissue stretch ex vivo and in vivo. Here, we tested the hypothesis that fibroblasts, through this cytoskeletal remodeling, actively contribute to the visco-elastic behavior of the whole tissue.

Langevin, Helene M.
Bouffard, Nicole A.
Fox, James R.
Palmer, Bradley M.
Wu, Junru
Iatridis, James C.
Barnes, William D.
Badger, Gary J.
Howe, Alan K.
Publication Title: 
Journal of Neuroinflammation

BACKGROUND: Activation of glial cells, including astrocytes and microglia, has been implicated in the inflammatory responses underlying brain injury and neurodegenerative diseases including Alzheimer's and Parkinson's diseases. Although cultured astrocytes and microglia are capable of responding to pro-inflammatory cytokines and lipopolysaccharide (LPS) in the induction and release of inflammatory factors, no detailed analysis has been carried out to compare the induction of iNOS and sPLA2-IIA.

Sheng, Wenwen
Zong, Yijia
Mohammad, Arwa
Ajit, Deepa
Cui, Jiankun
Han, Dongdong
Hamilton, Jennifer L.
Simonyi, Agnes
Sun, Albert Y.
Gu, Zezong
Hong, Jau-Shyong
Weisman, Gary A.
Sun, Grace Y.
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