Pyocyanine

Publication Title: 
Free Radical Biology & Medicine

Pyocyanin (N-methyl-1-hydroxyphenazine), a redox-active virulence factor produced by the human pathogen Pseudomonas aeruginosa, is known to compromise mucociliary clearance. Exposure of human bronchial epithelial cells to pyocyanin increased the rate of cellular release of H(2)O(2) threefold above the endogenous H(2)O(2) production.

Author(s): 
Schwarzer, Christian
Fischer, Horst
Kim, Eun-Jin
Barber, Katharine J.
Mills, Aaron D.
Kurth, Mark J.
Gruenert, Dieter C.
Suh, Jung H.
Machen, Terry E.
Illek, Beate
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