Rats, Wistar

Publication Title: 
Molecular and Cellular Biochemistry

Stress is one of the basic factors in the etiology of number of diseases. The present study was aimed to investigate the effect of Triphala (Terminalia chebula, Terminalia belerica and Emblica officinalis) on noise-stress induced alterations in the antioxidant status and on the cell-mediated immune response in Wistar strain male albino rats. Noise-stress employed in this study was 100 dB for 4 h/d/15 days and Triphala was used at a dose of 1 g/kg/b.w/48 days.

Author(s): 
Srikumar, Ramasundaram
Parthasarathy, Narayanaperumal Jeya
Manikandan, Sundaramagalingam
Narayanan, Govindarajulu Sathya
Sheeladevi, Rathinasamy
Publication Title: 
Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)

Nickel, a major environmental pollutant is a known potent nephrotoxic agent. In this communication we report the chemopreventive effect of Terminalia chebula on nickel chloride (NiCl(2)) induced renal oxidative stress, toxicity and cell proliferation response in male Wistar rats.

Author(s): 
Prasad, Lakshmi
Husain Khan, Tajdar
Jahangir, Tamanna
Sultana, Sarwat
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Triphala (Terminalia chebula, Terminalia belerica, and Emblica officinalis) on total cholesterol, Low density lipoprotein (LDL), Very low density lipoprotein (VLDL), High density lipoprotein (HDL) and free fatty acid in experimentally induced hypercholesteremic rats.

Author(s): 
Saravanan, Selvaraj
Srikumar, Ramasundaram
Manikandan, Sundaramahalingam
Jeya Parthasarathy, Narayanaperumal
Sheela Devi, Rathinasamy
Publication Title: 
The Journal of Surgical Research

BACKGROUND: Infection is a major problem in the management of wounds. Even though the development of synthetic antimicrobial agents persists, drug resistance and toxicity hinder their way. Many plants with multi-potent pharmaceutical activities may offer better treatment options, and Triphala (dried fruits of Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica) are potential formulations evaluated for healing activity on infected wound as it possesses numerous activities.

Author(s): 
Kumar, Muthusamy Senthil
Kirubanandan, Shanmugam
Sripriya, Ramasamy
Sehgal, Praveen Kumar
Publication Title: 
Chemico-Biological Interactions

Mitochondria play a central role in molecular events leading to tissue damage in ischemia. The present study examines the role of the alcoholic extract of T. chebula (TCE) pretreatment (50 mg/100 g body weight) to attenuate the isoproterenol (ISO) (20mg/100g body wt, sc) induced alterations on heart mitochondrial ultrastucture and function in experimental rats.

Author(s): 
Suchalatha, Subramaniyan
Srinivasan, Periasamy
Devi, Chennam Srinivasulu Shyamala
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Stress is one of the basic factors in the etiology of number of diseases. Cold-stress occurs when the surrounding temperature drops below 18 degrees C, the body may not be able to warm itself, and hence serious cold-related illnesses, permanent tissue damage and death may results.

Author(s): 
Dhanalakshmi, Selvakumar
Devi, Rathinasamy Sheela
Srikumar, Ramasundaram
Manikandan, Sundaramahalingam
Thangaraj, Ramasundaram
Publication Title: 
Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association

The aqueous extract of the fruits of Terminalia chebula Retz. has been evaluated for its antidiabetic activity in streptozotocin (STZ) induced mild diabetic rats and compared with a known drug, tolbutamide. The oral effective dose (ED) of the extract was observed to be 200 mg/kg body weight, which produced a fall of 55.6% (p<0.01) in the oral glucose tolerance test.

Author(s): 
Murali, Y. K.
Anand, P.
Tandon, V.
Singh, R.
Chandra, R.
Murthy, P. S.
Publication Title: 
Die Pharmazie

In an effort to identify a new chemopreventive agent, the present study was conducted to investigate the role of T. chebula in the prevention of ferric nitrilotriacetic acid (Fe- NTA) induced oxidative stress and renal tumorigenesis in Wistar rats. A single application of Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) significantly induced oxidative stress and elevated the marker parameters of tumor promotion. However, the pretreatment of animals with different doses of T.

Author(s): 
Prasad, L.
Khan, T. H.
Jahangir, T.
Sultana, S.
Publication Title: 
Phytotherapy research: PTR

Triphala is categorized as a rejuvenator and antioxidant-rich Ayurvedic herbal formulation and has traditionally been used in various gastric problems including intestinal inflammation. The aim of the present study was to examine the comparative enteroprotective effect of Triphala formulations against methotrexate-induced intestinal damage in rats. Triphala formulations were prepared by mixing equal (1:1:1) and unequal (1:2:4) proportions of Terminalia chebula Retz., Terminalia belerica (Gaertn.) Roxb. and Emblica officinalis Gaertn.

Author(s): 
Nariya, Mukeshkumar
Shukla, Vinay
Jain, Sunita
Ravishankar, Basavaiah
Publication Title: 
Phytotherapy research: PTR

There is documented evidence of the use of Terminalia chebula for various ailments in the Ayurvedic literature. The extract has been shown to possess glucose lowering activity and to improve insulin sensitivity in animal models of type 2 diabetes mellitus. The present study was carried out to study the dose response relationship of this extract in a rat model of metabolic syndrome. Six groups of rats were fed a high fructose diet (HFD) for a period of 20 days to induce metabolic syndrome. Three doses of fruit extract of T.

Author(s): 
Singh, Inderjeet
Singh, Pawan Kumar
Bhansali, Shobhit
Shafiq, Nusrat
Malhotra, Samir
Pandhi, Promila
Pal Singh, Amrit

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