Receptors, Notch

Publication Title: 
Breast Cancer Research and Treatment

Ayurvedic medicine plants continue to draw attention for the discovery of novel anticancer agents. Withaferin A (WA) is one such small-molecule constituent of the ayurvedic medicine plant Withania somnifera with efficacy against cultured and xenografted human breast cancer cells. However, the mechanism underlying anticancer effect of WA is not fully understood. This study was undertaken to determine the role of Notch signaling in anticancer effects of WA using human breast cancer cells as a model. Notably, Notch signaling is often hyperactive in human breast cancers.

Author(s): 
Lee, Joomin
Sehrawat, Anuradha
Singh, Shivendra V.
Publication Title: 
Breast Cancer Research and Treatment

Ayurvedic medicine plants continue to draw attention for the discovery of novel anticancer agents. Withaferin A (WA) is one such small-molecule constituent of the ayurvedic medicine plant Withania somnifera with efficacy against cultured and xenografted human breast cancer cells. However, the mechanism underlying anticancer effect of WA is not fully understood. This study was undertaken to determine the role of Notch signaling in anticancer effects of WA using human breast cancer cells as a model. Notably, Notch signaling is often hyperactive in human breast cancers.

Author(s): 
Lee, Joomin
Sehrawat, Anuradha
Singh, Shivendra V.
Publication Title: 
Anticancer Research

BACKGROUND/AIM: Zeng Sheng Ping (ZSP) is a traditional herbal remedy used to prevent progression and growth of neoplastic lesions. It has been shown to inhibit Notch2 expression in a murine lung cancer model, leading us to investigate its therapeutic potential in Notch-dependent brain tumors.

Author(s): 
Lim, Kah Jing
Rajan, Kda
Eberhart, Charles G.
Publication Title: 
BMC neuroscience

BACKGROUND: Electroacupuncture (EA) pretreatment can induce the tolerance against focal cerebral ischemia. However, the underlying mechanisms have not been fully understood. Emerging evidences suggest that canonical Notch signaling may be involved in ischemic brain injury. In the present study, we tested the hypothesis that EA pretreatment-induced tolerance against focal cerebral ischemia is mediated by Notch signaling.

Author(s): 
Zhao, Yu
Chen, Xiyao
Ma, Lei
Zuo, Zhiyi
Zhu, Zhenghua
Zhu, Xiaoling
Wang, Qiang
He, Ertao
Xiong, Lize
Pei, Jianming
Xu, Lixian
Hou, Lihong
Chen, Shaoyang
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