Serotonin Plasma Membrane Transport Proteins

Publication Title: 
Tsitologiia

Interdisciplinary study of telomere length, polymorphism of genes of renin-angiotensin (ACE) and serotonin (5HTR2A and 5HTTPR) systems in population of aged and old inhabitants of the North-West of Russia was conducted, in their relations to data from clinical and geriatric anamnesis, and psychological functioning. Regular link between telomere length and respondent's age was demonstrated in subgroups of old respondents and long-livers, by method of factor analysis.

Author(s): 
Smirnova, T. Iu
Runov, A. L.
Vonski?, M. S.
Spivak, D. L.
Zakharchuk, A. G.
Mikhel'son, V. M.
Spivak, I. M.
Publication Title: 
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics

The serotonin reuptake transporter (5HTT) is thought to be the principal regulator of serotonergic activity and epigenetic effects at this locus are thought to be important moderators of vulnerability to neuropsychiatric illness. In attempt to understand the basis of this regulation, several gene polymorphisms that affect 5HTT mRNA levels have been described. But to date, no clear mechanism linking these polymorphisms to vulnerability to epigenetic effects have been described.

Author(s): 
Philibert, Robert
Madan, Anup
Andersen, Allan
Cadoret, Remi
Packer, Hans
Sandhu, Harinder
Publication Title: 
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics

Serotonin Transporter (5HTT or SLC6A4) mRNA transcription is regulated by both genetic and epigenetic mechanisms. Unfortunately, despite intense scrutiny, the exact identity and contribution of each of these regulatory mechanisms, and their relationship to behavioral illness remain unknown. This lack of knowledge is critical because alterations in SLC6A4 function are posited to be central to a wide variety of CNS disorders.

Author(s): 
Philibert, Robert A.
Sandhu, Harinder
Hollenbeck, Nancy
Gunter, Tracy
Adams, William
Madan, Anup
Publication Title: 
Current Psychiatry Reports

Attention-deficit/hyperactivity disorder (ADHD) is among the most common childhood-onset psychiatric disorders. Although family, twin, and adoption studies demonstrate that ADHD is a highly heritable condition, studies also suggest that genetic architecture is complex, prompting the use of more advanced methodologies such as genome-wide linkage and association studies. Although such studies are theoretically compelling, replication of these results has been inconsistent.

Author(s): 
Smith, Alicia K.
Mick, Eric
Faraone, Stephen V.
Publication Title: 
Schizophrenia Research

A 44 base pair insertion ("l")/deletion ("s") polymorphism (called 5-HTTLPR) in the 5' promoter region of the human serotonin transporter gene (SLC6A4) modulates expression and has been associated to anxiety and depressive traits in otherwise healthy individuals. In individuals with psychiatric diagnoses, including schizophrenia, it seems to modulate symptom severity. Thus, it may be a disease modifying gene.

Author(s): 
Goldberg, Terry E.
Kotov, Roman
Lee, Annette T.
Gregersen, Peter K.
Lencz, Todd
Bromet, Evelyn
Malhotra, Anil K.
Publication Title: 
Genes, Brain, and Behavior

Epigenetic mechanisms may moderate genetic and environmental risk (GxE) for mood disorders. We used an experimental rhesus macaque model of early life stress to test whether epigenetic regulation of serotonin transporter (5-HTT) may contribute to GxE interactions that influence behavior and emotion.

Author(s): 
Kinnally, E. L.
Capitanio, J. P.
Leibel, R.
Deng, L.
LeDuc, C.
Haghighi, F.
Mann, J. J.
Publication Title: 
Epigenetics

DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been associated with disease susceptibility. The degree to which changes in loci-specific DNA methylation are under the influence of heritable and environmental factors is largely unknown.

Author(s): 
Wong, Chloe Chung Yi
Caspi, Avshalom
Williams, Benjamin
Craig, Ian W.
Houts, Renate
Ambler, Antony
Moffitt, Terrie E.
Mill, Jonathan
Publication Title: 
Biological Psychiatry

BACKGROUND: Do genetic or epigenetic factors play a role in making some individuals more vulnerable than others to loss of attachment figures or other traumatic experiences? METHODS: DNA was obtained from growth phase entrained Epstein-Barr Virus (EBV) transformed lymphoblast cell lines from 143 adopted participants. Genotype of the serotonin transporter linked polymorphic region (5HTTLPR) was determined, and methylation ratios for each of the C-phosphate-G (CpG) residues were assessed using quantitative mass spectroscopy.

Author(s): 
van IJzendoorn, Marinus H.
Caspers, Kristin
Bakermans-Kranenburg, Marian J.
Beach, Steven R. H.
Philibert, Robert
Publication Title: 
The Israel Journal of Psychiatry and Related Sciences

Major depressive disorder (MDD) is a heterogeneous, highly prevalent, and moderately heritable disorder. A complex and diverse genetic-environmental interplay converges to set apart a significant minority that is susceptible to MDD, from among those who experience shorter lived and less recurrent intensive and incapacitating forms of sadness.

Author(s): 
Goltser-Dubner, Tanya
Galili-Weisstub, Esti
Segman, Ronnen H.
Publication Title: 
Psychosomatic Medicine

OBJECTIVE: To examine epigenetic processes linking childhood sex abuse to symptoms of antisocial personality disorder (ASPD) in adulthood and to investigate the possibility that the link between childhood sex abuse and deoxyribonucleic acid methylation at the 5HTT promoter might represent a pathway of long-term impact on symptoms of ASPD. METHOD: Deoxyribonucleic acid was prepared from lymphoblast cell lines derived from 155 female participants in the latest wave of the Iowa Adoptee Study.

Author(s): 
Beach, Steven R. H.
Brody, Gene H.
Todorov, Alexandre A.
Gunter, Tracy D.
Philibert, Robert A.

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