Serotonin Uptake Inhibitors

Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Premature ejaculation (PE) is commonly defined as ejaculation with minimal sexual stimulation before, on or shortly after penetration and before the person wishes it. PE can be either lifelong and present since first sexual experiences (primary), or acquired (secondary), beginning later (Godpodinoff ML. Premature ejaculation: clinical subgroups and etiology. J Sex Marital Ther 1989;15:130-4). Treatments include behavioural and pharmacological interventions.

Author(s): 
Cooper, Katy
Martyn-St James, Marrissa
Kaltenthaler, Eva
Dickinson, Kath
Cantrell, Anna
Publication Title: 
Obstetrics and Gynecology

OBJECTIVE: To describe the effects of six interventions for menopausal vasomotor symptoms relative to control in a pooled analysis, facilitating translation of the results for clinicians and symptomatic women. The Menopause Strategies: Finding Lasting Answers for Symptoms and Health network tested these interventions in three randomized clinical trials. METHODS: An analysis of pooled individual-level data from three randomized clinical trials is presented. Participants were 899 perimenopausal and postmenopausal women with at least 14 bothersome vasomotor symptoms per week.

Author(s): 
Guthrie, Katherine A.
LaCroix, Andrea Z.
Ensrud, Kristine E.
Joffe, Hadine
Newton, Katherine M.
Reed, Susan D.
Caan, Bette
Carpenter, Janet S.
Cohen, Lee S.
Freeman, Ellen W.
Larson, Joseph C.
Manson, JoAnn E.
Rexrode, Kathy
Skaar, Todd C.
Sternfeld, Barbara
Anderson, Garnet L.
Publication Title: 
Mayo Clinic Proceedings

The objective of the International Society for the Study of Women's Sexual Health expert consensus panel was to develop a concise, clinically relevant, evidence-based review of the epidemiology, physiology, pathogenesis, diagnosis, and treatment of hypoactive sexual desire disorder (HSDD), a sexual dysfunction affecting approximately 10% of adult women. Etiologic factors include conditions or drugs that decrease brain dopamine, melanocortin, oxytocin, and norepinephrine levels and augment brain serotonin, endocannabinoid, prolactin, and opioid levels.

Author(s): 
Goldstein, Irwin
Kim, Noel N.
Clayton, Anita H.
DeRogatis, Leonard R.
Giraldi, Annamaria
Parish, Sharon J.
Pfaus, James
Simon, James A.
Kingsberg, Sheryl A.
Meston, Cindy
Stahl, Stephen M.
Wallen, Kim
Worsley, Roisin
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: This is an updated version of the Cochrane review published in 2005 on selective serotonin re-uptake inhibitors (SSRIs) for preventing migraine and tension-type headache. The original review has been split in two parts and this review now only regards tension-type headache prevention. Another updated review covers migraine. Tension-type headache is the second most common disorder worldwide and has high social and economic relevance.

Author(s): 
Banzi, Rita
Cusi, Cristina
Randazzo, Concetta
Sterzi, Roberto
Tedesco, Dario
Moja, Lorenzo
Publication Title: 
Health Technology Assessment (Winchester, England)

BACKGROUND: Premature ejaculation (PE) is commonly defined as ejaculation with minimal sexual stimulation before, on or shortly after penetration and before the person wishes it. PE can be either lifelong and present since first sexual experiences (primary), or acquired (secondary), beginning later (Godpodinoff ML. Premature ejaculation: clinical subgroups and etiology. J Sex Marital Ther 1989;15:130-4). Treatments include behavioural and pharmacological interventions.

Author(s): 
Cooper, Katy
Martyn-St James, Marrissa
Kaltenthaler, Eva
Dickinson, Kath
Cantrell, Anna
Publication Title: 
Journal of Psychopharmacology (Oxford, England)

We describe a patient with depression who was well controlled with sertraline monotherapy developing two relapses of depression in close temporal relationship with starting ayurvedic herbal mixtures. We discuss the possibility of a pharmacokinetic herb-drug interaction decreasing the therapeutic efficacy of sertraline leading to the relapses of depression. We speculate the herbal plant most likely to be responsible for this interaction is either Terminalia chebula or Commiphora wighteii.

Author(s): 
Prasad, K. P. R. C.
Tharangani, P. G. D.
Samaranayake, C. N.
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

OBJECTIVES: The "neurotrophin hypothesis" of depression posits a role of brain-derived neurotrophic factor (BDNF) in depression, although it is unknown whether BDNF is more involved in the etiology of depression or in the mechanism of action of antidepressants. It is also unknown whether pre-treatment serum BDNF levels predict antidepressant response. METHODS: Thirty un-medicated depressed subjects were treated with escitalopram (N=16) or sertraline (N=14) for 8 weeks. Twenty-five of the depressed subjects completed 8 weeks of antidepressant treatment and had analyzable data.

Author(s): 
Wolkowitz, Owen M.
Wolf, Jessica
Shelly, Wendy
Rosser, Rebecca
Burke, Heather M.
Lerner, George K.
Reus, Victor I.
Nelson, J. Craig
Epel, Elissa S.
Mellon, Synthia H.
Publication Title: 
Journal of Affective Disorders

Some patients with obsessive-compulsive disorder (OCD) exhibit an unsatisfactory reduction in symptom severity despite being treated with all the available therapeutic alternatives. The clinical variables associated with treatment-refractoriness in OCD are inconsistently described in the literature. METHODS: To investigate factors associated with treatment-refractoriness of patients with OCD, we conducted a case-control study, comparing 23 patients with treatment-refractory OCD to 26 patients with treatment-responding OCD.

Author(s): 
Ferr„o, Ygor A.
Shavitt, Roseli G.
Bedin, N·dia R.
de Mathis, Maria EugÍnia
Carlos Lopes, AntÙnio
Fontenelle, Leonardo F.
Torres, Albina R.
Miguel, EurÌpedes C.
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

The selective serotonin reuptake inhibitor (SSRI) ProzacÆ (fluoxetine) is widely prescribed for the treatment of depression and anxiety-related disorders. While extensive research has established that fluoxetine is safe for adults, safety is not guaranteed for (unborn) children and adolescents. Some clinical studies have reported adverse outcomes, such as premature birth, neonatal cardiovascular abnormalities, and pulmonary hypertension in children whose mothers used SSRIs during pregnancy.

Author(s): 
Olivier, J. D. A.
Blom, T.
Arentsen, T.
Homberg, J. R.
Publication Title: 
The Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine

Finely tuning levels of the key neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) during early life is essential for brain development and setting pathways for health and disorder across the early life span. Given the central role of 5-HT in brain development, regulation of mood, stress reactivity, and risk for psychiatric disorders, alterations in 5-HT signaling early in life have critical implications for behavior and mental health in childhood and adolescence.

Author(s): 
Oberlander, Tim F.

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