Spermatogenesis

Publication Title: 
Reproductive Toxicology (Elmsford, N.Y.)

Our interest in development of hyaluronidase inhibitors as male antifertility agents led to identification of Terminalia chebula (T. chebula) plant with hyaluronidase (HAase) inhibitory activity of human spermatozoa ( approximately 93% inhibition) and rat caudal epididymal spermatozoa ( approximately 86% inhibition) in vitro at 30 mg/ml.

Author(s): 
Srivastav, Archana
Chandra, Abhishek
Singh, Madhulika
Jamal, Farrukh
Rastogi, Preeti
Rajendran, Siron Mani
Bansode, Falgun Wanganuji
Lakshmi, Vijai
Publication Title: 
PloS One

BACKGROUND: The Ayurvedic medicinal system claims Mucuna pruriens (MP) to possess pro-male fertility, aphrodisiac and adaptogenic properties. Some scientific evidence also supports its pro-male fertility properties; however, the mechanism of its action is not yet clear. The present study aimed at demonstrating spermatogenic restorative efficacy of MP and its major constituent L-DOPA (LD), and finding the possible mechanism of action thereof in a rat model.

Author(s): 
Singh, Akhand Pratap
Sarkar, Saumya
Tripathi, Muktanand
Rajender, Singh
Publication Title: 
Andrologia

The safety and spermatogenic activity of processed Shilajit (PS) were evaluated in oligospermic patients. Initially, 60 infertile male patients were assessed and those having total sperm counts below 20 million ml(-1) semen were considered oligospermic and enrolled in the study (n = 35). PS capsule (100 mg) was administered twice daily after major meals for 90 days. Total semenogram and serum testosterone, luteinising hormone and follicle-stimulating hormone were estimated before and at the end of the treatment.

Author(s): 
Biswas, T. K.
Pandit, S.
Mondal, S.
Biswas, S. K.
Jana, U.
Ghosh, T.
Tripathi, P. C.
Debnath, P. K.
Auddy, R. G.
Auddy, B.
Publication Title: 
Andrologia

A number of herbal drugs are advocated in the traditional Ayurvedic literature for the improvement of overall sexual function. Young roots of Bombax ceiba Linn. (Fam. Bombacaceae) [correction added after online publication 1 August 2011: the family of Bombax ceiba was incorrectly mentioned as Orchidaceae. It has been corrected to Bombacaceae] also known as Semal Musli are used traditionally in Indian subcontinent as sexual stimulant. Its juice is considered nutritive and restorative tonic.

Author(s): 
Bhargava, C.
Thakur, M.
Yadav, S. K.
Publication Title: 
Phytotherapy research: PTR

Anacyclus pyrethrum (A. pyrethrum) has been used as Vajikaran Rasayana (aphrodisiac) in traditional Indian ayurvedic medicine to treat male sexual dysfunction, including infertility. Aphrodisiac activity may be due to an increase in the production or effect of androgens, so this study sought to evaluate the androgenic and spermatogenic potential of the alkylamide-rich ethanol solution extract. Male Wistar strain rats weighing between 150 and 180 g were completely randomized divided into five groups. The ethanol solution extract of A.

Author(s): 
Sharma, Vikas
Boonen, Jente
Spiegeleer, Bart De
Dixit, V. K.
Publication Title: 
PloS One

BACKGROUND: The Ayurvedic medicinal system claims Mucuna pruriens (MP) to possess pro-male fertility, aphrodisiac and adaptogenic properties. Some scientific evidence also supports its pro-male fertility properties; however, the mechanism of its action is not yet clear. The present study aimed at demonstrating spermatogenic restorative efficacy of MP and its major constituent L-DOPA (LD), and finding the possible mechanism of action thereof in a rat model.

Author(s): 
Singh, Akhand Pratap
Sarkar, Saumya
Tripathi, Muktanand
Rajender, Singh
Publication Title: 
Reproduction (Cambridge, England)

We have recently reported that adult male C57BL/6 mice exposed in utero to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) confer an increased risk of preterm birth (PTB) to unexposed females. Risk of PTB was coincident with decreased placental progesterone receptor (Pgr) mRNA expression and increased toll-like receptor 4 (Tlr4) mRNA expression, suggesting that toxicant exposure induced a heightened inflammatory response at the maternal-fetal interface.

Author(s): 
McConaha, Melinda E.
Ding, Tianbing
Lucas, John A.
Arosh, Joe A.
Osteen, Kevin G.
Bruner-Tran, Kaylon L.
Publication Title: 
FASEB journal: official publication of the Federation of American Societies for Experimental Biology

The protein encoded by the sirt1 gene is an enzyme, SirT1, that couples the hydrolysis of NAD(+) to the deacetylation of acetyl-lysine residues in substrate proteins. Mutations of the sirt1 gene that fail to encode protein have been introduced into the mouse germ line, and the animals homozygous for these null mutations have various physiological abnormalities.

Author(s): 
Seifert, Erin L.
Caron, Annabelle Z.
Morin, Katy
Coulombe, Josée
He, Xiao Hong
Jardine, Karen
Dewar-Darch, Danielle
Boekelheide, Kim
Harper, Mary-Ellen
McBurney, Michael W.
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