Publication Title: 
Caries Research

There are over 750 species of bacteria that inhabit the human oral cavity, but only a small fraction of those are attributed to causing plaque-related diseases such as caries. Streptococcus mutans is accepted as the main cariogenic agent and there is substantial knowledge regarding the specific virulence factors that render the organism a pathogen. There has been rising interest in alternative, target-specific treatment options as opposed to nonspecific mechanical plaque removal or application of broad-spectrum antibacterials that are currently in use.

Yoo, S.
Murata, R. M.
Duarte, S.
Publication Title: 
Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Postmenopausal women with osteopenia received green tea polyphenols (GTP) supplement and/or Tai Chi exercise for 6 months. Bone turnover biomarkers, calcium metabolism, and muscle strength were measured. This study showed that GTP supplementation and Tai Chi exercise increased bone formation biomarkers and improved bone turnover rate. Tai Chi exercise increased serum parathyroid hormone. GTP supplementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia.

Shen, C.-L.
Chyu, M.-C.
Yeh, J. K.
Zhang, Y.
Pence, B. C.
Felton, C. K.
Brismée, J.-M.
Arjmandi, B. H.
Doctolero, S.
Wang, J.-S.
Publication Title: 
Analytical Chemistry

There is potential that the pathological effects of oxidative stress (OS) associated diseases such as diabetes could be ameliorated with antioxidants, but this will require a clearer understanding of the pathway(s) by which proteins are damaged by OS. This study reports the development and use of methods that assess the efficacy of dietary antioxidant supplementation at a mechanistic level. Data reported here evaluate the impact of green tea supplementation on oxidative stress induced post-translational modifications (OSi-PTMs) in plasma proteins of Zucker diabetic fatty (ZDF) rats.

Madian, Ashraf G.
Myracle, Angela D.
Diaz-Maldonado, Naomi
Rochelle, Nishi S.
Janle, Elsa M.
Regnier, Fred E.
Publication Title: 
PloS One

Melanoma is the most serious type of skin disease and a leading cause of death from skin disease due to its highly metastatic ability. To develop more effective chemopreventive agents for the prevention of melanoma, we have determined the effect of green tea catechins on the invasive potential of human melanoma cells and the molecular mechanisms underlying these effects using A375 (BRAF-mutated) and Hs294t (Non-BRAF-mutated) melanoma cell lines as an in vitro model.

Singh, Tripti
Katiyar, Santosh K.
Publication Title: 
Journal of Food Science

Although heme iron is an important form of dietary iron, its intestinal absorption mechanism remains elusive. Our previous study revealed that (-)-epigallocatechin-3-gallate (EGCG) and grape seed extract (GSE) markedly inhibited intestinal heme iron absorption by reducing the basolateral iron export in Caco-2 cells. The aim of this study was to examine whether small amounts of EGCG, GSE, and green tea extract (GT) could inhibit heme iron absorption, and to test whether the inhibitory action of polyphenols could be offset by ascorbic acid.

Ma, Qianyi
Kim, Eun-Young
Lindsay, Elizabeth Ann
Han, Okhee
Publication Title: 
Molecular Nutrition & Food Research

SCOPE: Hyperglycemia-induced vascular inflammation resulting in the adhesion of monocytes to endothelium is a key event in the pathogenesis of atherosclerosis in diabetes. We investigated whether epigallocatechin gallate (EGCG), a major catechin found in green tea, reduces vascular inflammation in diabetes. METHODS AND RESULTS: Human aortic endothelial cells (HAEC) were pretreated with green tea catechins before the addition of high glucose (25 mM) for 72 h.

Babu, Pon V. Anandh
Si, Hongwei
Liu, Dongmin
Publication Title: 
European Journal of Nutrition

PURPOSE: Tea (Camellia sinensis) is a widely consumed beverage, and laboratory and some intervention studies have indicated the potential health benefits of hot tea. The present study examines the association between tea consumption (evaluating hot and iced tea independently) and markers for metabolic syndrome adults in a sample of 6,472 who participated in the 2003-2006 National Health and Nutrition Examination surveys. METHODS: Tea consumption was evaluated using food frequency questionnaires and 24-h dietary recalls.

Vernarelli, Jacqueline A.
Lambert, Joshua D.
Publication Title: 
Molecular Nutrition & Food Research

SCOPE: Green tea has been shown to ameliorate symptoms of metabolic syndrome in vivo. The effects could be due, in part, to modulation of postprandial blood glucose levels. METHODS AND RESULTS: We examined the effect of coadministration of (-)-epigallocatechin-3-gallate (EGCG, 100 mg/kg, i.g.) on blood glucose levels following oral administration of common corn starch (CCS), maltose, sucrose, or glucose to fasted CF-1 mice.

Forester, Sarah C.
Gu, Yeyi
Lambert, Joshua D.
Publication Title: 

Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited.

Du, Guang-Jian
Zhang, Zhiyu
Wen, Xiao-Dong
Yu, Chunhao
Calway, Tyler
Yuan, Chun-Su
Wang, Chong-Zhi
Publication Title: 
PloS One

Inactivation of the tumor suppressor gene p53 is commonly observed in human prostate cancer and is associated with therapeutic resistance. We have previously demonstrated that green tea polyphenols (GTP) induce apoptosis in prostate cancer cells irrespective of p53 status. However, the molecular mechanisms underlying these observations remain elusive. Here we investigated the mechanisms of GTP-induced apoptosis in human prostate cancer LNCaP cells stably-transfected with short hairpin-RNA against p53 (LNCaPshp53) and control vector (LNCaPshV).

Gupta, Karishma
Thakur, Vijay S.
Bhaskaran, Natarajan
Nawab, Akbar
Babcook, Melissa A.
Jackson, Mark W.
Gupta, Sanjay


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