Tubulin Modulators

Publication Title: 
Journal of Cellular Physiology

The visco-elastic behavior of connective tissue is generally attributed to the material properties of the extracellular matrix rather than cellular activity. We have previously shown that fibroblasts within areolar connective tissue exhibit dynamic cytoskeletal remodeling within minutes in response to tissue stretch ex vivo and in vivo. Here, we tested the hypothesis that fibroblasts, through this cytoskeletal remodeling, actively contribute to the visco-elastic behavior of the whole tissue.

Author(s): 
Langevin, Helene M.
Bouffard, Nicole A.
Fox, James R.
Palmer, Bradley M.
Wu, Junru
Iatridis, James C.
Barnes, William D.
Badger, Gary J.
Howe, Alan K.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Roots of Galianthe thalictroides K. Schum. (Rubiaceae) are used in folk medicine in the State of Mato Grosso do Sul, Brazil, for treating and preventing cancer. To gain information about the genotoxicity of extracts (aqueous and EtOH), the CHCl₃ phase resulting from partition of the EtOH extract and the indole monoterpene alkaloid 1 obtained from this plant. The genotoxicity of 1 and extracts was evaluated in vivo through the Drosophila melanogaster wing Somatic Mutation and Recombination Test - SMART, while in vitro cytotoxic (MTT) and Comet assays were performed only with alkaloid 1.

Author(s): 
Fernandes, L. M.
Garcez, W. S.
Mantovani, M. S.
Figueiredo, P. O.
Fernandes, C. A.
Garcez, F. R.
Guterres, Z. R.
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