Tumor Necrosis Factor-alpha

Publication Title: 
PloS One

IMPORTANCE: Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined. OBJECTIVE: To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses. METHODS: Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013.

Author(s): 
Morgan, Nani
Irwin, Michael R.
Chung, Mei
Wang, Chenchen
Publication Title: 
PloS One

IMPORTANCE: Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined. OBJECTIVE: To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses. METHODS: Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013.

Author(s): 
Morgan, Nani
Irwin, Michael R.
Chung, Mei
Wang, Chenchen
Publication Title: 
PloS One

IMPORTANCE: Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined. OBJECTIVE: To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses. METHODS: Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013.

Author(s): 
Morgan, Nani
Irwin, Michael R.
Chung, Mei
Wang, Chenchen
Publication Title: 
Journal of Ethnopharmacology

We investigated the effects of the water soluble fraction of Terminalia chebula (Combretaceae) (WFTC) on systemic and local anaphylaxis. WFTC administered 1h before compound 48/80 injection inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.01-1.0 g/kg. When WFTC was administered 5 or 10 min after compound 48/80 injection, the mortality also decreased in a dose-dependent manner. Passive cutaneous anaphylaxis was inhibited by 63.5+/-7.8% by oral administration of WFTC (1.0 g/kg).

Author(s): 
Shin, T. Y.
Jeong, H. J.
Kim, D. K.
Kim, S. H.
Lee, J. K.
Kim, D. K.
Chae, B. S.
Kim, J. H.
Kang, H. W.
Lee, C. M.
Lee, K. C.
Park, S. T.
Lee, E. J.
Lim, J. P.
Kim, H. M.
Lee, Y. M.
Publication Title: 
The Journal of Pharmacy and Pharmacology

OBJECTIVE: This study evaluates the anti-arthritic effect of Terminalia chebula hydroalcoholic extract (TCHE) in experimental models and attempts to correlate the effect of treatment on macrophage-derived pro-inflammatory cytokine expression and extent of disease activity. METHODS: Arthritis was induced in rats by subplantar administration of either formaldehyde or complete Freund's adjuvant (CFA). Joint size was measured at regular intervals by using a micrometer screw gauge.

Author(s): 
Nair, Vinod
Singh, Surender
Gupta, Yogendra Kumar
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Helicobacter pylori infection is associated with gastritis, peptic ulcer, and gastric cancer. Due to its high global prevalence and uprising resistance to available antibiotics, efforts are now directed to identify alternative source to treat and prevent associated disorders.

Author(s): 
Zaidi, Syed Faisal
Muhammad, Jibran Sualeh
Shahryar, Saeeda
Usmanghani, Khan
Gilani, Anwarul-Hassan
Jafri, Wasim
Sugiyama, Toshiro
Publication Title: 
Phytotherapy research: PTR

Eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between DNA and NF-kB, a transcription factor involved in the expression of proinflammatory genes. Cystic fibrosis (CF) cell line stimulated by TNF-? has been used as inflammatory cellular model to determinate interleukin-8 (IL-8), one of the most relevant pro-inflammatory mediator in CF regulated by the NF-kB.

Author(s): 
Guerrini, Alessandra
Mancini, Irene
Maietti, Silvia
Rossi, Damiano
Poli, Ferruccio
Sacchetti, Gianni
Gambari, Roberto
Borgatti, Monica
Publication Title: 
Medical Science Monitor: International Medical Journal of Experimental and Clinical Research

BACKGROUND: Cystatin C (cC) is a cysteine protease inhibitor that may influence immune response. Our aim was to test the effect of a high concentration of cC, characteristic for uremic patients, on neutrophil (PMN) apoptosis and respiratory burst, as well as the cC secretion from PMNs stimulated with proinflammatory cytokines. MATERIAL/METHODS: PMNs from 35 healthy volunteers aged 27-61 years were cultured in presence of cC, IL-1beta or TNF-alpha. The percentage of apoptotic cells based on DNA depletion, Fas, FasL and caspase -3 expression were assessed.

Author(s): 
Majewska, Ewa
Wittek, Natalia
Rysz, Jacek
Baj, Zbigniew
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

One of the most robust observations in the biology of aging is that caloric restriction (CR) extends life in a variety of species. Although CR results in a severalfold decrease in fat mass (FM), the role of fat on life extension was considered to be minimal. Two main reasons accounted for this belief. First, although increased FM is associated with changes in substrate oxidation and in glucose homeostasis, in part through the effects of free fatty acids (FFA) and glycerol, several studies have suggested that longevity is determined independent of FM.

Author(s): 
Barzilai, N.
Gupta, G.
Publication Title: 
Prostaglandins, Leukotrienes, and Essential Fatty Acids

GLUT-4 (glucose transporter) receptor, tumor necrosis factor-alpha (TNF-alpha), interleukins-6 (IL-6), daf-genes and PPARs (peroxisomal proliferation activator receptors) play a role in the development of insulin resistance syndrome and associated conditions. But, the exact interaction between these molecules/factors and the mechanism(s) by which they produce insulin resistance syndrome is not clear.

Author(s): 
Das, Undurti N.

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