Tumor Suppressor Protein p53

Publication Title: 
European Journal of Pharmacology

Bioactive compounds found in many plant species have been used in Chinese, Unani, and Indian ayurvedic medicine. Accumulative evidences in both in vitro and in vivo studies using berberine demonstrated anti-cancer and anti-inflammatory properties in different cancer cells. In the present study, a putative compound from commercial sample was purified by chromatographic techniques. The structure of the pure compound was confirmed by spectroscopic studies.

Author(s): 
Patil, Jeevitha B.
Kim, Jinhee
Jayaprakasha, G. K.
Publication Title: 
Molecular Carcinogenesis

We have shown previously that withaferin A (WA), a promising anticancer constituent of Ayurvedic medicine plant Withania somnifera, inhibits growth of MCF-7 and MDA-MB-231 human breast cancer cells in culture and MDA-MB-231 xenografts in vivo by causing apoptosis. However, the mechanism of WA-induced apoptosis is not fully understood. The present study was designed to systematically determine the role of tumor suppressor p53 and estrogen receptor-α (ER-α) in proapoptotic response to WA using MCF-7, T47D, and ER-α overexpressing MDA-MB-231 cells as a model.

Author(s): 
Hahm, Eun-Ryeong
Lee, Joomin
Huang, Yi
Singh, Shivendra V.
Publication Title: 
PloS One

The present day lifestyle heavily depends on industrial chemicals in the form of agriculture, cosmetics, textiles and medical products. Since the toxicity of the industrial chemicals has been a concern to human health, the need for alternative non-toxic natural products or adjuvants that serve as antidotes are in high demand. We have investigated the effects of Ayurvedic herb Ashwagandha (Withania somnifera) leaf extract on methoxyacetic acid (MAA) induced toxicity.

Author(s): 
Priyandoko, Didik
Ishii, Tetsuro
Kaul, Sunil C.
Wadhwa, Renu
Publication Title: 
BMC medicine

BACKGROUND: The mangosteen fruit has a long history of medicinal use in Chinese and Ayurvedic medicine. Recently, the compound α-mangostin, which is isolated from the pericarp of the fruit, was shown to induce cell death in various types of cancer cells in in vitro studies. This led us to investigate the antitumor growth and antimetastatic activities of α-mangostin in an immunocompetent xenograft model of mouse metastatic mammary cancer having a p53 mutation that induces a metastatic spectrum similar to that seen in human breast cancers.

Author(s): 
Shibata, Masa-Aki
Iinuma, Munekazu
Morimoto, Junji
Kurose, Hitomi
Akamatsu, Kanako
Okuno, Yasushi
Akao, Yukihiro
Otsuki, Yoshinori
Publication Title: 
PloS One

BACKGROUND AND PURPOSE: Withanolides are naturally occurring chemical compounds. They are secondary metabolites produced via oxidation of steroids and structurally consist of a steroid-backbone bound to a lactone or its derivatives. They are known to protect plants against herbivores and have medicinal value including anti-inflammation, anti-cancer, adaptogenic and anti-oxidant effects. Withaferin A (Wi-A) and Withanone (Wi-N) are two structurally similar withanolides isolated from Withania somnifera, also known as Ashwagandha in Indian Ayurvedic medicine.

Author(s): 
Vaishnavi, Kirti
Saxena, Nishant
Shah, Navjot
Singh, Rumani
Manjunath, Kavyashree
Uthayakumar, M.
Kanaujia, Shankar P.
Kaul, Sunil C.
Sekar, Kanagaraj
Wadhwa, Renu
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Centratherum anthelminticum (L.) Kuntze (scientific synonyms: Vernonia anthelmintica; black cumin) is one of the ingredients of an Ayurvedic preparation, called "Kayakalp", commonly applied to treat skin disorders in India and Southeast Asia. Despite its well known anti-inflammatory property on skin diseases, the anti-cancer effect of C. anthelminticum seeds on skin cancer is less documented.

Author(s): 
Looi, Chung Yeng
Moharram, Bushra
Paydar, Mohammadjavad
Wong, Yi Li
Leong, Kok Hoong
Mohamad, Khalit
Arya, Aditya
Wong, Won Fen
Mustafa, Mohd Rais
Publication Title: 
Free Radical Biology & Medicine

Apigenin, a plant flavone, potentially activates wild-type p53 and induces apoptosis in cancer cells. We conducted detailed studies to understand its mechanism of action. Exposure of human prostate cancer 22Rv1 cells, harboring wild-type p53, to growth-suppressive concentrations (10-80 microM) of apigenin resulted in the stabilization of p53 by phosphorylation on critical serine sites, p14ARF-mediated downregulation of MDM2 protein, inhibition of NF-kappaB/p65 transcriptional activity, and induction of p21/WAF-1 in a dose- and time-dependent manner.

Author(s): 
Shukla, Sanjeev
Gupta, Sanjay
Publication Title: 
Carcinogenesis

Ulcerative colitis (UC) is a dynamic, idiopathic, chronic inflammatory condition associated with a high colon cancer risk. American ginseng has antioxidant properties and targets many of the players in inflammation. The aim of this study was to test whether American ginseng extract prevents and treats colitis. Colitis in mice was induced by the presence of 1% dextran sulfate sodium (DSS) in the drinking water or by 1% oxazolone rectally.

Author(s): 
Jin, Yu
Kotakadi, Venkata S.
Ying, Lei
Hofseth, Anne B.
Cui, Xiangli
Wood, Patricia A.
Windust, Anthony
Matesic, Lydia E.
Pena, Edsel A.
Chiuzan, Codruta
Singh, Narendra P.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Wargovich, Michael J.
Hofseth, Lorne J.
Publication Title: 
Nutrition and Cancer

One approach to control colorectal cancer (CRC) is its preventive intervention by dietary agents or those consumed as supplements. However, because most of these products are often consumed by patients as an complementary and alternative medicine practice, a scientific base such as efficacy, mechanism, and standardized preparation needs to be developed. Grape seed extract (GSE) is one such supplement widely consumed by humans for its several health benefits. We reported recently that GSE inhibits CRC cell HT29 growth in culture and nude mice xenograft.

Author(s): 
Kaur, Manjinder
Mandair, Reinuka
Agarwal, Rajesh
Agarwal, Chapla
Publication Title: 
International Journal of Oncology

In spite of the global consumption of mushrooms, only two epidemiological studies demonstrated an inverse correlation between mushroom intake and the risk of cancer. Therefore, in the present study we evaluated whether extracts from edible mushrooms Agaricus bisporus (portabella), Flammulina velutipes (enoki), Lentinula edodes (shiitake) and Pleurotus ostreatus (oyster) affect the growth of breast and colon cancer cells. Here, we identified as the most potent, P.

Author(s): 
Jedinak, Andrej
Sliva, Daniel

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